Show simple item record

dc.contributor.authorCariño Cortés, Raquelen_US
dc.date.accessioned2013-11-05T22:01:13Z
dc.date.available2013-11-05T22:01:13Z
dc.date.issued2009en_US
dc.identifier.citationOrtiz MI, Cariño-Cortés R, Pérez-Hernández N, Ponce-Monter H, Fernández-Martínez E, Castañeda-Hernández G, Acosta-Madrid II, Cilia-López VG Antihyperalgesia Induced by Heliopsis longipes Extract. Proc West Pharmacol Soc. 2009;52:75-77. ISSN: 0083-8969.es
dc.identifier.urihttps://repository.uaeh.edu.mx/bitstream/handle/123456789/11950
dc.description.abstractHeliopsis longipes is an herbaceous plant found in Mexico. Heliopsis longipes is traditionally used for its analgesic and anesthetic properties. Plant extracts may represent a therapeutic advantage for the clinical treatment of pain. Therefore, the main objective of this study was to determine the possible antihyperalgesic effect produced by the Heliopsis longipes ethanolic extract (HLEE) in the Hargreaves model of thermal hyperalgesia in the mouse. HLEE was administrated systemically to mice and the antihyperalgesic effect was evaluated using the thermal hyperalgesia test. Oral Administration of HLEE produced a dose-dependent antihyperalgesic effect. Previously, it was reported that Heliopsis longipes extract was able to release GABA in mice temporal cortex slices. Therefore, it is likely that the antihyperalgesic effect observed in our study could result from GABA liberation and its inhibition of excessive excitation of nociceptive circuits in the thalamus and cortex evoked by tissue injury. Our results suggest that HLEE may represent a therapeutic advantage for the clinical treatment of inflammatory pain.es
dc.languageesen_US
dc.subjectGenética Toxicológicaes
dc.titleAntihyperalgesia Induced by Heliopsis longipes Extractes
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record