Obesidad y aterosclerosis; principales factores de riesgo que desarrollan la Calcificación Cardiovascular

Abstract

Cardiovascular calcification has been observed in the vasculature of the arteries for many decades, but recently, this phenomenon was seen simply as a passive consequence of aging. Nowadays, the accumulation of evidence points to a strictly regulated process, with competition between the inhibitory factors and the factors that promote mineralization. In spite of all these years of study, the mechanism of the moment in which the process of vascular protection is broken where the process of deregulation and the increase of the oxidative stress is promoted has not been clarified. Therefore, the process is developed inflammatory and degenerative vascular endothelium that occurs during cardiovascular calcification. In this review, we report the findings that have been published in recent years of the mechanism of cardiovascular calcification formation, promoted by the oxidative stress microenvironment and the ratio of the reduction of antioxidants during the process deregulation and development of this pathological process.