dc.contributor.author | Zepeda Bastida, Armando | en_US |
dc.date.accessioned | 2013-11-04T21:38:27Z | |
dc.date.available | 2013-11-04T21:38:27Z | |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Chiquete-Felix, N., Hernández, J. M., Méndez, J. A., Zepeda-Bastida, A., Chagolla-López, A. y A. Mújica. 2009. In guinea pig sperm, aldolase A forms a complex with actin, WAS, and Arp2/3 that plays a role in actin polymerization. Reproduction 137(4):669-78. Preprinted | es |
dc.identifier.uri | https://repository.uaeh.edu.mx/bitstream/handle/123456789/7491 | |
dc.description.abstract | Glycolytic enzymes have, in addition to their role in energy production, other functions in the regulation of cellular processes. Aldolase A has been reported to be present in sperm, playing a key role in glycolysis; however, despite its reported interactions with actin andWAS, little is known about a non-glycolytic role of aldolase A in sperm. Here, we show that in guinea pig spermatozoa, aldolase A is tightly associated to cytoskeletal structures where it interacts with actin, WAS, and Arp2/3. We show that aldolase A spermatozoa treatment increases their polymerized actin levels. In addition, we show that there is a direct correlation between the levels of polymerized actin and the levels of aldolase A actin interaction. Our results suggest that aldolase A functions as a bridge between filaments of actin and the actin-polymerizing machinery. | es |
dc.language | es | en_US |
dc.subject | Biotecnología aplicada a las ciencias veterinarias | es |
dc.title | In guinea pig sperm, aldolase A forms a complex with actin, WAS, and Arp2/3 that plays a role in actin polymerization | es |
dc.type | Other | en_US |