| dc.description.abstract | Tissue degeneration, infection, inflammation, cancer, trauma, surgery and limb
fractures all produce pain. Each of these physiological abnormalities requires a
therapeutic approach different from the last. In acute pain, caused by fracture,
several classes of analgesics have been utilized. These basic remedies for
analgesia, however, are still confined to a small number of medications, including
nonsteroidal anti-inflammatory drugs (NSAIDs), local anesthetics and opioids. In
addition, most of these drugs have side effects, limiting their use in clinical
practice. The purpose of this study was to compare the efficacy of three NSAIDs
to relief acute pain caused by ankle fracture. Sixty subjects with ankle fracture
were randomized to receive ketorolac, diclofenac, or etoricoxib, every 12 hours in
a prospective, double-blind study. Forty-nine patients completed the study. The
subjects’ assessments of ankle pain on the visual analog scale and a Likert scale
showed a significant reduction from baseline over 24 hr, regardless the treatment
group. | es |
Universidad Autónoma del Estado de Hidalgo
