Browsing Medicina by Subject "Toxicología Preclínica"
Now showing items 1-20 of 21
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Antinociceptive, genotoxic and histopathological study of Heliopsis longipes S.F. Blake in mice
(2010)Ethnopharmacological relevance: H. longipes S.F. Blake (Asteraceae) is a Mexican plant, whose roots aretraditionally used as a condiment, as a mouth anesthetic, and as an antiparasitic. Affinin is the alkamidepresent in ... -
Cytotoxic and Antiproliferative Effect of Tepary Bean Lectins on C33-A, MCF-7, SKNSH, and SW480 Cell Lines
(2014)For many years, several studies have been employing lectin from vegetables in order to prove its toxic effect on various cell lines. In this work, we analyzed the cytotoxic, antiproliferative, and post-incubatory effect ... -
Decreased in vitro fertility in male rats exposed to fluoride-induced oxidative stress damage and mitochondrial transmembrane potential loss
(2008)Fluorosis, caused by drinking water contamination with inorganic fluoride, is a public health problem inmany areas around the world. The aim of the study was to evaluate the effect of environmentally relevantdoses of ... -
Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A)
(2011)Lectins comprise a heterogeneous class of proteins that recognize thecarbohydrate moieties of glycoconjugates with high specificity. Numerous studies haveOPEN ACCESSMolecules 2011, 162108shown that lectins are capable of ... -
Effect of dietary selenium deficiency on the in vitro fertilizing ability of mice spermatozoa
(2008)Selenium is an essential micronutrient formammals, being integral part of antioxidant system.The aim of the study was to evaluate the effect ofselenium deficiency on in vitro fertilization (IVF)capacity of spermatozoa and ... -
Effectiveness of Diclofenac, Ketorolac and Etoricoxib in the Treatment of Acute Pain from Ankle Fracture
(2010)Tissue degeneration, infection, inflammation, cancer, trauma, surgery and limb fractures all produce pain. Each of these physiological abnormalities requires a therapeutic approach different from the last. In acute pain, ... -
Exposure to bisphenol A in young adult mice does not alter ovulation but does alter the fertilization ability of oocytes
(2015)"Follicle growth culminates in ovulation, which allows for the expulsion of fertilizable oocytes and the formation of corpora lutea. Bisphenol A (BPA) is present in many consumer products, and it has been suggested that ... -
Investigation on the Protective Effect of ?-Mannan against the DNA Damage Induced by Aflatoxin B1 in Mouse Hepatocytes
(2009)Aflatoxin B1 is a contaminant of agricultural and dairy products that can berelated to mutagenic and carcinogenic effects. In this report we explore the capacity of ?-mannan (Man) to reduce the DNA damage induced by AFB1 ... -
Lead, Cadmium and Cobalt (Pb, Cd, and Co) Leaching of Glass-Clay Containers by pH Effect of Food
(2011)Recent studies have shown that handcrafted glass-clay containers are a health risk because they can be contaminated by heavy metals, which can be transferred to food, thus reaching the human body to potentially cause ... -
Methamidophos alters sperm function and DNA at different stages of spermatogenesis in mice
(2014)Methamidophos (MET) is a highly toxic organophosphate (OP) pesticide that is widely used in developing countries. MET has male reproductive effects, including decreased fertility. We evaluated MET effects on sperm quality, ... -
Methyl-parathion decreases sperm function and fertilization capacity after targeting spermatocytes and maturing spermatozoa
(2009)Paternal germline exposure to organophosphorous pesticides (OP) has been associated with reproductivefailures and adverse effects in the offspring. Methyl-parathion (Me-Pa), a worldwide-used OP, hasreproductive adverse ... -
Pharmacological Interaction between Gabapentin and Glibenclamide in the Formalin Test in the Diabetic Rat
(2010)There is evidence that local peripheral administration of gabapentin produces antinociception through the activation of the ATP-sensitive K+-channel. However, this interaction has not been evaluated systemically, nor in ... -
Pharmacovigilance of Psychoactive Medications in a Mexican Psychiatric Hospital
(2010)Pharmacovigilance is the permanent collection and assessment of the safety data of drugs in the interest of precise knowledge of the safety profile. We monitored notifications of suspected adverse reactions (AR) produced ... -
Presence, processing, and localization of mouse ADAM15 during sperm maturation and the role of its disintegrin domain during sperm egg binding
(2008)Successful fertilization requires gametes to complete several stages, beginning with maturation and transport along the male and femalereproductive tracts and ending with the interaction between the sperm and the egg. This ... -
Prevention of Aflatoxin B?-Induced DNA Breaks by ?-D-Glucan
(2015)"Aflatoxins are a group of naturally-occurring carcinogens that are known to contaminate different human and animal foodstuffs. Aflatoxin B1 (AFB1) is the most genotoxic hepatocarcinogenic compound of all of the aflatoxins. ... -
Prevention of Aflatoxin B?-Induced DNA Breaks by ?-D-Glucan
(2015)"Aflatoxins are a group of naturally-occurring carcinogens that are known to contaminate different human and animal foodstuffs. Aflatoxin B1 (AFB1) is the most genotoxic hepatocarcinogenic compound of all of the aflatoxins. ... -
Protective Effect of Resveratrol on Biomarkers of Oxidative Stress Induced by Iron/Ascorbate in Mouse Spermatozoa
(2014)Resveratrol (RVT) is a polyphenolic compound found mainly in the grape and attributed with various pharmacological properties, among them their antioxidant activity. In the present study, we assess the antioxidant activity ... -
Protective Effect of Resveratrol on Biomarkers of Oxidative Stress Induced by Iron/Ascorbate in Mouse Spermatozoa
(2014)Resveratrol (RVT) is a polyphenolic compound found mainly in the grape and attributed with various pharmacological properties, among them their antioxidant activity. In the present study, we assess the antioxidant activity ... -
Purification, Biochemical Characterization, and Bioactive Properties of a Lectin Purified from the Seeds of White Tepary Bean (Phaseolus Acutifolius Variety Latifolius)
(2011)The present work shows the characterization of Phaseolus acutifolius varietylatifolius, on which little research has been published, and provides detailed information onthe corresponding lectin. This protein was purified ...