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dc.contributor.authorMorales González, Jose Antonioen_US
dc.date.accessioned2013-11-05T22:00:12Z
dc.date.available2013-11-05T22:00:12Z
dc.date.issued2010en_US
dc.identifier.citationMorales-González JA, Gutiérrez-Salinas J, García-Ortiz L, Del Carmen Chima-Galán M, Madrigal-Santillán E, Esquivel-Soto J, Esquivel-Chirino C, González-Rubio MG. Effect of sodium fluoride ingestion on malondialdehyde concentration and the activity of antioxidant enzymes in rat erythrocytes. Int J Mol Sci. 2010; 11:2443-52. ISSN: 1422-0067es
dc.identifier.urihttps://repository.uaeh.edu.mx/bitstream/handle/123456789/11925
dc.description.abstractFluoride intoxication has been shown to produce diverse deleterious metabolic alterations within the cell. To determine the effects of sodium fluoride (NaF) treatment on malondialdehyde (MDA) levels and on the activity of antioxidant enzymes in rat erythrocytes, Male Wistar rats were treated with 50 ppm of NaF or were untreated as controls. Erythrocytes were obtained from rats sacrificed weekly for up to eight weeks and the concentration of MDA in erythrocyte membrane was determined. In addition, the activity of the enzymes superoxide, dismutase, catalase, and glutathione peroxidase were determined. Treatment with NaF produces an increase in the concentration of malondialdehyde in the erythrocyte membrane only after the eight weeks of treatment. On the other hand, antioxidant enzyme activity was observed to increase after the fourth weekOPEN ACCESSInt. J. Mol. Sci. 2010, 11 2444of NaF treatment. In conclusion, intake of NaF produceses
dc.languageesen_US
dc.subjectGenética Toxicológicaes
dc.titleEffect of Sodium Fluoride Ingestion on Malondialdehyde Concentration and the Activity of Antioxidant Enzymes in Rat Erythrocyteses
dc.typeArticleen_US


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