Lack of effects of acemetacin on signalling pathways for leukocyte adherence may explain its gastrointestinal safety

Abstract

Acemetacin is a non-steroidal anti-inflammatory drug which is rapidly bioconverted to indomethacin, but produces significantly less gastric damage than indomethacin. This study was performed to investigate several possible mechanisms that could account for the gastrointestinal tolerability of acemetacin.