Universidad Autónoma del Estado de Hidalgo
    • English
    • español
  • English 
    • English
    • español
  • Login
View Item 
  •   RIA-UAEH Home
  • Ciencias de la Salud
  • Medicina
  • Presentaciones electrónicas
  • View Item
  •   RIA-UAEH Home
  • Ciencias de la Salud
  • Medicina
  • Presentaciones electrónicas
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Interacción Sinérgica entre la Lidocaína y Lumiracoxib en la prueba de formalina 1% en ratas

Thumbnail
View/Open
INTERACCION_LIDOCAINA_Y_LUMIRACOXIB.pdf (487.1Kb)
Date
2011
Author
Ponce Monter, Héctor Antonio
Izquierdo Vega, Jeannett Alejandra
Ortíz Ramírez, Mario
Metadata
Show full item record
Abstract
It has been shown that the association of non-steroidal anti-inflammatory drugs (NSAIDs) with analgesic agents can increase their antinociceptive activity, allowing the use of lower doses and thus limiting side effects. Therefore, the aim of the present study was to examine the possible pharmacological interaction between lumiracoxib and lidocaine at the local peripheral level in the rat using the 1% formalin test and isobolographic analysis. Lumiracoxib, lidocaine or fixed-dose ratio (1:1) lumiracoxib-lidocaine combinations were administered locally in the formalin-injured paw and the antinociceptive effect was evaluated. All treatments produced a dose-dependent antinociceptive effect. ED40 values were estimated for the individual drugs and an isobologram was constructed. The derived theoretical ED40 for the lumiracoxiblidocaine combination was 599.3 ± 58.8 µg/paw, being significantly higher than the actually observed experimental ED40 value, 393.6 ± 39.7 µg/paw. This result correspond to a synergistic interaction between lumiracoxib and lidocaine at the local peripheral level, potency being about one and half times higher with regard to that expected from the addition of the effects of the individual drugs. Data suggest that low doses of the lumiracoxib-lidocaine combination can interact synergistically at the peripheral level and therefore this drug association may represent a therapeutic advantage for the clinical treatment of procedural or inflammatory pain.
URI
https://repository.uaeh.edu.mx/bitstream/handle/123456789/13982
Collections
  • Presentaciones electrónicas

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.

Theme by 
@mire NV
 

 

Browse

All of RIA-UAEHCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.

Theme by 
@mire NV