Obesidad y aterosclerosis; principales factores de riesgo que desarrollan la Calcificación Cardiovascular
Abstract
Cardiovascular calcification has been observed in the vasculature of the arteries for
many decades, but recently, this phenomenon was seen simply as a passive
consequence of aging. Nowadays, the accumulation of evidence points to a strictly
regulated process, with competition between the inhibitory factors and the factors
that promote mineralization. In spite of all these years of study, the mechanism of
the moment in which the process of vascular protection is broken where the
process of deregulation and the increase of the oxidative stress is promoted has
not been clarified. Therefore, the process is developed inflammatory and
degenerative vascular endothelium that occurs during cardiovascular calcification.
In this review, we report the findings that have been published in recent years of
the mechanism of cardiovascular calcification formation, promoted by the oxidative
stress microenvironment and the ratio of the reduction of antioxidants during the
process deregulation and development of this pathological process.