Quantification and electrochemical characterization of diclofenac in carbon paste and carbon nanotube composite electrode
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) share similar pharmacological actions and undesirable effects. Within the widely prescribed and known drugs, diclofenac exhibits anti-inflammatory, analgesic and antipyretic properties. High consume of this drug has made necessary its control and regulation in pharmaceutical samples. In the present work we propose a methodology to detect and quantify diclofenac.
Quantitation is directly made in aqueous medium, using a carbon paste electrode with carbon nanotubes as working electrode. Diclofenac electrochemistry is analyzed by cyclic voltammetry, with an oxidation peak at a potential of 0.61 V. pH 8 resulted to be the best resulting in a sensitivity of 0.194 ± 0.09 uA / μmolL-1, detection limit of 0.74 μmolL-1 and quantitation limit of 2.49 μmolL-1, indicating that this could be an alternative to quantify diclofenac in pharmaceutical samples, with better analytical parameters than those reported in literature.
Downloads
References
[2]. R Roskar, V Kmetec: Biomed. Chromatogr, 2003, vol. 5, pp. 57–64.
[3]. R. Bhushan, D. Gupta, A. Mukherjee: Biomed. Chromatogr, 2007, vol. 21, pp.1284-1290.
[4]. W. Jin, J. Zhang: Chromatography A, 2000, vol. 868, pp. 101–107.
[5]. M.C.B. López, J.L. Castañón, A.J.M. Ordieres, P.T. Blanco: Anal Bioanal Chem, 2003, vol. 377, pp. 257–261.
[6]. X. Yang, F. Wang, S. Hu: Mater. Sci. Electrochem., 2012, vol. 7, pp. 2109 – 2122.
[7]. Rajendra N. Goyal, Sanghamitra Chatterjee, Bharati Agrawal: Sensors and Actuators, 2010, vol. B145, pp. 743–748.
[8]. H. Karimi-Maleh, M. Moazampour, H. Ahmar, H. Beitollahi, A.A. Ensafi: Measurement, 2014, vol. 51, pp. 91–99.
[9]. A.A. Ensafi, H. Karimi-Maleh, S. Mallakpour, B. Rezaei: Colloids Surf., 2011, Vol. B 87, pp. 480–488.
[10]. J.B. Raoof, R. Ojani, H. Karimi-Maleh: 2009, Appl. Electrochem., Vol. 39, 1169–1175.
