Uso de soluciones antisépticas para reducir la carga viral del SARS CoV-2 en la atención odontológica Review
DOI:
https://doi.org/10.29057/icsa.v14i27.12628Palabras clave:
Enjuague bucal, SARS CoV-2, Antisépticos orales, COVID-19Resumen
Luego de que se reportara el primer caso de una nueva enfermedad que genero conmoción a nivel mundial, el SARS CoV-2 nos dio la oportunidad de concientizar como debería ser la atención odontológica en el futuro, ya que la OMS emitió un comunicado donde recomendaba suspender la atención odontología convencional a todos los odontólogos del mundo y la atención bucodental se limitó a atender casos de extrema urgencia y bajo un protocolo sanitario más controlado.
Algunos reportes que sugieren la reducción de la carga viral de COVID-19 en la cavidad oral cuando el paciente realiza enjuagues bucales con soluciones cuya formulación estén presente clorhexidina, peróxido de hidrógeno, yodopovidona, cetil piridino, cloruro de benzalconio, etanol y algunos aceites esenciales; en razón de que la Norma Oficial mexicana NOM-013-SSA2-2015, que establece los métodos, técnicas y criterios de operación del sistema nacional de salud, basándose en los niveles de prevención, control y vigilancia epidemiológica de las enfermedades bucales de mayor frecuencia en nuestro país no ha sido actualizada la siguiente revisión tiene como objetivo conocer las propuestas preventivas que se pueden incorporar en la atención bucodental.
Buscamos literatura publicada en la biblioteca PubMed, SciELO y Google Scholar desde diciembre de 2019 hasta marzo de 2025, con el objetivo de recabar la mayor cantidad de datos reportados con respecto a la reducción de la carga viral del SAR-Cov- 2 por uso de soluciones antisépticas durante la atención odontológica.
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[1] World Health Organization (WHO). Coronavirus disease (COVID-19) Situation Report-191, 2020. Ginebra, World Health Organization, 2020.
[2] Sharma, A., Ahmad Farouk, I., & Lal, S. K. COVID-19: A Review on the Novel Coronavirus Disease Evolution, Transmission, Detection, Control and Prevention. Viruses, 2021. 13(2), 202.
[3] Long, B., Carius, B. M., Chavez, S., Liang, S. Y., Brady, W. J., Koyfman, A., & Gottlieb, M. Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation. The American journal of emergency medicine, 2022. 54, 46–57.
[4] Yoon JG, Yoon J, Song JY, et al. Clinical significance of a high SARS-CoV2 viral load in the saliva. J Korean Med Sci. 2020; 35(20):e195.
[5] Chen, M. H., & Chang, P. C. The effectiveness of mouthwash against SARS-CoV-2 infection: A review of scientific and clinical evidence. Journal of the Formosan Medical Association = Taiwan yi zhi, 2022, 121(5), 879–885.
[6] Gao, J. C., Hood, C., Safai, B., & Marmon, S. Evidence for the use of mouthwash as a preprocedural preventive measure against COVID-19: Should we rinse and repeat? JAAD international, 2022, 6, 109–110
[7] Rahman, G. S., Alshetan, A. A. N., Alotaibi, S. S. O., Alaskar, B. M. I., & Baseer, M. A. Is chlorhexidine mouthwash effective in lowering COVID-19 viral load? A systematic review. European review for medical and pharmacological sciences, 2023, 27(1), 366–377.
[8] Elzein, R., Abdel-Sater, F., Fakhreddine, S., Hanna, P. A., Feghali, R., Hamad, H., & Ayoub, F. In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial. The journal of evidence-based dental practice, 2021, 21(3), 101584.
[9] Fernandez, M. D. S., Guedes, M. I. F., Langa, G. P. J., Rösing, C. K., Cavagni, J., & Muniz, F. W. M. G. Virucidal efficacy of chlorhexidine: a systematic review. Odontology, 2022, 110(2), 376–392.
[10] Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coro-naviruses on inanimate surfaces and their inactivation with bio-cidal agents. J Hosp Infect 2020;104:246e51.
[11] Caruso A A, Del Prete A, Lazzarino A I, Capaldi R ,Grumetto L. May hydrogen peroxide reduce the hospitalization rate and complications of SARS-CoV2infection?InfectControlHospEpidemiol 2020;22:1e2.
[12] Gottsauner, M. J., Michaelides, I., Schmidt, B., Scholz, K. J., Buchalla, W., Widbiller, M., Hitzenbichler, F., Ettl, T., Reichert, T. E., Bohr, C., Vielsmeier, V., & Cieplik, F. A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2. Clinical oral investigations, 2022, 24(10), 3707–3713.
[13] Alzahrani, M. M., Bamashmous, S., Alkharobi, H., Alghamdi, A., Alharbi, R. H., Hassan, A. M., Darwish, M., Bukhari, A., Mahmoud, A. B., Alfaleh, M. A., Mirza, A. A., Abuzenadah, A. M., Abujamel, T. S., & Hashem, A. M. Mouth rinses efficacy on salivary SARS-CoV-2 viral load: A randomized clinical trial. Journal of medical virology, 2023, 95(1), e28412.
[14] Meyers C, Robison R, Milici J, et al. Lowering the transmission and spread of human coronavirus. J Med Virol. 2021;93(3):1605‐1612.
[15] Pablo-Marcos, D., Abascal, B., Lloret, L., Gutiérrez Cuadra, M., Velasco, N., & Valero, C. Utility of mouth rinses with povidone-iodine and hydrogen peroxide in patients with COVID-19. Enfermedades infecciosas y microbiologia clinica (English ed.), 2023, 41(3), 173–175.
[16] Amoah, A. G. B., Sagoe, K. W., Quakyi, I. A., Ayettey Anie, H. N. G., Ayettey-Adamafio, M. N. B., Ayettey Brew, R. N. A., Newman-Nartey, M., Nartey, N. O., Brightson, K. T. C., Kessie, G., Ayettey, A. S., & Konotey-Ahulu, F. I. D. Further observations on hydrogen peroxide antisepsis and COVID-19 cases among healthcare workers and inpatients. The Journal of hospital infection, 2022, 126, 103–108
[17] Tarragó-Gil, R., Gil-Mosteo, M. J., Aza-Pascual-Salcedo, M., Alvarez, M. J. L., Ainaga, R. R., Gimeno, N. L., Viñuales, R. F., Fernández, Y. M., Marco, J. M., Bolsa, E. A., Sancho, J. B., Cajo, S. A., Perez-Zsolt, D., Raïch-Regué, D., Muñoz-Basagoiti, J., Izquierdo-Useros, N., Pociello, V. B., León, R., & Peris, D. S. Randomized clinical trial to assess the impact of oral intervention with cetylpyridinium chloride to reduce salivary SARS-CoV-2 viral load. Journal of clinical periodontology, 2023, 50(3), 288–294.
[18] Filippo, D., Matteo, M., Marco, S., Marilena, M., Bernadette, C. M., Lloyd-Jones, G., & Alberto, Z. Efficacy of cetylpyridinium chloride mouthwash against SARS-CoV-2: A systematic review of randomized controlled trials. Molecular oral microbiology, 2023, 10.1111/omi.12408.
[19] Hernández-Vásquez, A., Barrenechea-Pulache, A., Comandé, D., & Azañedo, D. Mouthrinses and SARS-CoV-2 viral load in saliva: a living systematic review. 2022 Evidence-based dentistry, 1–7. Advance online publication
[20] Ziaeefar, P., Bostanghadiri, N., Yousefzadeh, P., Gabbay, J., Shahidi Bonjar, A. H., Ghazizadeh Ahsaie, M., Centis, R., Sabeti, M., Sotgiu, G., Migliori, G. B., & Nasiri, M. J. The efficacy of mouthwashes in reducing SARS-CoV-2 viral loads in human saliva: A systematic review. New microbes and new infections, 2022, 49, 101064.
[21] Schürmann M, Aljubeh M, Tiemann C, Sudhoff H. Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a clinical pilot study. Eur Arch Otorhinolaryngol 2021; 278: 5059-5067.
[22] Meza-Zegarra K, López Flores A. Efecto del enjuague bucal con cloruro de cetilpiridinio en la microdureza superficial del polimetilmetacrilato de autocurado, termocurado y CAD CAM. Estudio in vitro. Rev Cient Odontol (Lima). 2025;13(1):e227. doi: 10.21142/2523-2754-1301-2025-227.
[23] Poleti, M. L., Gregório, D., Bistaffa, A. G. I., Fernandes, K. B. P., Vilhena, F. V., Santos, P. S. D. S., Simão, A. N. C., Lozovoy, M. A. B., Tatibana, B. T., & Fernandes, T. M. F. Use of mouthwash and dentifrice containing an antimicrobial phthalocyanine derivative for the reduction of clinical symptoms of covid-19: a randomized triple-blind clinical trial. The journal of evidence-based dental practice, 2022, 22(4), 101777
[24] Stathis, C., Victoria, N., Loomis, K., Nguyen, S. A., Eggers, M., Septimus, E., & Safdar, N. Review of the use of nasal and oral antiseptics during a global pandemic. Future microbiology, 2021, 16(2), 119–130
[25] Seneviratne, C. J., Balan, P., Ko, K. K. K., Udawatte, N. S., Lai, D., Ng, D. H. L., Venkatachalam, I., Lim, K. S., Ling, M. L., Oon, L., Goh, B. T., & Sim, X. Y. J. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Infection, 2021, 49(2), 305–311
[26] Guenezan, J., Garcia, M., Strasters, D., Jousselin, C., Lévêque, N., Frasca, D., & Mimoz, O. Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial. JAMA otolaryngology-- head & neck surgery, 2021, 147(4), 400–401.
[27] Chopra, A., Sivaraman, K., Radhakrishnan, R., Balakrishnan, D., & Narayana, A. Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update. The Japanese dental science review, 2021, 57, 39–45
[28] Okeke, K. I., Ahamefule, C. S., Nnabuife, O. O., Orabueze, I. N., Iroegbu, C. U., Egbe, K. A., & Ike, A. C. (2024). Antiseptics: An expeditious third force in the prevention and management of coronavirus diseases. Current research in microbial sciences, 7, 100293. https://doi.org/10.1016/j.crmicr.2024.100293
[29] Hasan, F., Chiu, H. Y., Salamanca, E., Ridwan, E. S., Wiratama, B. S., & Budi, H. S. Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis. European journal of dentistry, 2022, 10.1055/s-0042-1753470.
[30] Anwandter, Andrés, Lefno-Diocares, Cristóbal, Valeria, Camila, & Robledo, Diego. Povidona Yodada como Antiséptico Oral en la Reducción de la Carga Viral del SARS-CoV-2: Revisión de la Literatura. International journal of odontostomatology, 2021, 15(4), 997-1004
[31] Meister, T. L., Gottsauner, J. M., Schmidt, B., Heinen, N., Todt, D., Audebert, F., Buder, F., Lang, H., Gessner, A., Steinmann, E., Vielsmeier, V., Pfaender, S., & Cieplik, F. Mouthrinses against SARS-CoV-2 - High antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trial. Virus research, 2022, 316, 198791.
[32] Watanabe, N., Hirose, R., Yamauchi, K., Miyazaki, H., Bandou, R., Yoshida, T., Doi, T., Inoue, K., Dohi, O., Yoshida, N., Uchiyama, K., Ishikawa, T., Takagi, T., Konishi, H., Ikegaya, H., Nakaya, T., & Itoh, Y. Evaluation of Environmental Stability and Disinfectant Effectiveness for Human Coronavirus OC43 on Human Skin Surface. Microbiology spectrum, e0238122. 2023. Advance online publication.
[33] Hirose, R., Bandou, R., Ikegaya, H., Watanabe, N., Yoshida, T., Daidoji, T., Naito, Y., Itoh, Y., & Nakaya, T. Disinfectant effectiveness against SARS-CoV-2 and influenza viruses present on human skin: model-based evaluation. Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2021, 27(7), 1042.e1–1042.e4.
[34] Mateos-Moreno, M. V., Mira, A., Ausina-Márquez, V., & Ferrer, M. D. Oral antiseptics against coronavirus: in-vitro and clinical evidence. The Journal of hospital infection, 2021, 113, 30–43.
[35] Mezarina Mendoza, J. P. I., Trelles Ubillús, B. P., Salcedo Bolívar, G. T., Castañeda Palacios, R. D. P., Herrera Lopez, P. S. G., Padilla Rodríguez, D. A., & Uchima Koecklin, K. H. (2022). Antiviral effect of mouthwashes against SARS-COV-2: A systematic review. The Saudi dental journal, 34(3), 167–193. https://doi.org/10.1016/j.sdentj.2022.01.006.
[36] Statkute, E., Rubina, A., O'Donnell, VB, Thomas, DW, Stanton, RJ, 2020. La eficacia virucida de los componentes del enjuague bucal contra el SARS-CoV-2 in vitro. bioRxiv 21, 1–9. https://doi.org/10.1101/2020.11.13.381079
[37] Meza-Zegarra K, López Flores A. Efecto del enjuague bucal con cloruro de cetilpiridinio en la microdureza superficial del polimetilmetacrilato de autocurado, termocurado y CAD CAM. Estudio in vitro. Rev Cient Odontol (Lima). 2025;13(1):e227. doi: 10.21142/2523-2754-1301-2025-227.
[38] da Silva, J.K.R.; Figueiredo, P.L.B.; Byler, K.G.; Setzer, W.N. Essential Oils as Antiviral Agents, Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation. Int. J. Mol. Sci. 2020, 21, 3426.
[39] Vimalanathan, S.; Hudson, J. Anti-influenza virus activity of essential oils and vapors. Am. J. Essent. Oils Nat. Prod. 2014, 2, 47–53.
[40] Vardhan, S., & Sahoo, S. K. In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19. Computers in biology and medicine, 2020, 124, 103936.
[41] Tateyama-Makino, R., Abe-Yutori, M., Iwamoto, T., Tsutsumi, K., Tsuji, M., Morishita, S., Kurita, K., Yamamoto, Y., Nishinaga, E., & Tsukinoki, K. The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro. PloS one, 2021, 16(9), e0257705
[42] Tazawa, K., Jadhav, R., Azuma, M. M., Fenno, J. C., McDonald, N. J., & Sasaki, H. Hypochlorous acid inactivates oral pathogens and a SARS-CoV-2-surrogate. BMC oral health, 2023; 23(1), 111.
[43] Huang N, Pérez P, Kato T, Mikami Y, Okuda K, Gilmore RC, et al. SARS-CoV-2 infection of the oral cavity and saliva. Nat Med. 2021;27:892–903.
[44] Chumpitaz-Cerrate, V., Chávez-Rimache, L., Ruiz-Ramirez, E., Franco-Quino, C., & Erazo-Paredes, C. Evaluation of Current Evidence on the Use of Oral Antiseptics Against SARS-CoV-2: A Narrative Review. Journal of International Society of Preventive & Community Dentistry, 2022, 12(5), 488–499.
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Derechos de autor 2025 Alelí Julieta Izquierdo Vega, Jeannett Alejandra Izquierdo-Vega, Manuel Sánchez- Gutiérrez , Jesús Carlos Ruvalcaba Ledezma

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.









