Risks due to COVID-19 during pregnancy, the effect of maternal obesity

Keywords: COVID-19, Pregnancy, Adipose Tissue, Obesity, SARS-CoV-2

Abstract

Currently, the information about COVID-19, obesity and pregnancy continues to have limitations. At the beginning of epidemic and in accordance with previous experience with other coronaviruses SARS and MERS, poor prognoses were expected for pregnant women with obesity who acquired the disease. Obesity is a chronic and low-grade inflammatory process, which has been associated with worse outcomes during pregnancy and COVID-19. The distribution of visceral adipose tissue is considered as poor prognostic and obese pregnant women have a higher risk of complications. Obese pregnant women have a higher risk of severe complications. The objective of this work was to review the evidence of the effect of obesity and COVID-19 in pregnancy.

Downloads

Download data is not yet available.

Author Biography

Guadalupe López-Rodríguez, Universidad Autónoma del Estado de Hidalgo

Profesor Investigador del Área Académica de Nutrición, ICSa-UAEH.

References

Huan H, Qingfeng M, Cong L, Rui L, Li Z, Wei W, et al. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerg Microbes Infect. 2020;9(1):1124-30.

Vega RG, Rico RM. Adipose tissue: immune function and alterations caused by obesity. Rev Alerg Méx. 2019;66(3):340-53.

Ovalle A, Martínez MA, Fuentes A, Marques X, Vargas F, Vergara P, et al. Obesity, a risk factor for ascending bacterial infection during pregnancy. Rev méd Chile. 2016;144(4):476-82.

McCartney SA, Kachikis A, Huebner EM, Walker CL, Chandrasekaran S, Adams WK. Obesity as a contributor to immunopathology in pregnant and non-pregnant adults with COVID-19. Am J Reprod Immunol. 2020;84:13320.

Petrakis D, Margină D, Tsarouhas K, Tekos F, Stan M, Nikitovic D, et al. Obesity a risk factor for increased COVID 19 prevalence, severity and lethality (Review). Mol Med Rep. 2020;22(1):9-19.

Panahi L, Amiri M, Pouy S. Risks of Novel Coronavirus Disease (COVID-19) in Pregnancy; a Narrative Review. Arch Acad Emerg Med. 2020;8(1):34.

Suárez-Carmona W, Sánchez-Oliver AJ, González-Jurado JA. Fisiopatología de la obesidad: Perspectiva actual. Rev Chil Nutr. 2017;44(3):226-33.

Engin AB. Adipocyte-Macrophage Cross-Talk in Obesity. Adv Exp Med Biol. 2017;960:327-43.

Michalakis K, Ilias I. SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects. Diabetes Metab Syndr. 2020;14(4):469-71.

Robertson SA, Petroff MG, Hunt JS. Immunology of pregnancy. Knobil and Neill's Physiology of Reproduction. 2015:1835-74.

Salazar TL, Ávila GD. Inmunología perinatal. FEMINA. 2014;42(4):186-92.

Aghaeepour N, Ganio EA, Mcilwain D, Tsai AS, Tingle M, Van GS, et al. An immune clock of human pregnancy. Sci Immunol. 2017;2(15):2946.

Herrera-Pérez JC, Monterio-Fonseca J, Campos-Sánchez S. COVID-19 y embarazo. Rev Méd Sinerg. 2020;5(9):492.

Encuesta Nacional de Salud y Nutrición 2018-19. Resultados nacionales. [Available from: https://ensanut.insp.mx/encuestas/ensanut2018/informes.php.

Rasmussen KM, Yaktine AL, Institute of Medicine (U.S.). Committee to Reexamine IOM Pregnancy Weight Guidelines. Weight gain during pregnancy: reexamining the guidelines. Washington, DC: National Academies Press; 2009. xiv, 854 p. p.

Guerendiain M. Impact of maternal obesity on fetal metabolic programming. Latin Perinat. 2016;19(2):152-6.

Mejia MJ, Reyna VE. Obesidad, insulinorresistencia e hipertensión durante el embarazo. Rev Venez Endocrinol Metab. 2017;15(3):169-81.

Stefan N, Birkenfeld AL, Schulze MB, al. e. Obesidad y deterioro de la salud metabólica en pacientes con COVID-19. Nat Rev Endocrinol. 2020;16:341-2.

Yang J, HU J, Zhu C. Obesity aggravates COVID-19: A systematic review and meta-analysis. J Med Virol. 2020;93(1):257-61.

Petersen A, Bressem K, Albrecht J, Thieb H, Vahldiek J, Hamm B, et al. The role of visceral adiposity in the severity of COVID-19: Highlights from a unicenter cross-sectorial pilot study in Germany. Metabolism Clinical and Experimental. 2020;110:317.

Watanabe M, Caruso D, Tuccinardi D, Risi R, Zerunian M, Polici M, et al. Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19. Metabolism. 2020;111:319.

Favre G, Legueult K, Pradier C, Raffaelli C, Ichai C, Iannelli A, et al. Visceral fat is associated to the severity of COVID-19. Metabolism. 2020;115:440.

Wastnedge E, Reynolds RM, van Boeckel SR, Stock SJ, Denison FC, Maybin JA, et al. Pregnancy and COVID-19. Physiol Rev. 2021;101(1):303-18.

Takemoto M, Menezes MO, Andreucci CB, Knobel R, Sousa L, Katz L, et al. Clinical characteristics and risk factors for mortality in obstetric patients with severe COVID-19 in Brazil: a surveillance database analysis. BJOG. 2020;127(13):1618-26.

Martinelli I, Ferrazzi E, Ciavarella A, Blasi F, Mosca F, Peyvandi F. Pulmonary embolism in a young pregnant woman with COVID-19. Thrombosis R. 2020;191:36-7.

Hayakawa S, Komine-Aizawa S, Gil GM. Covid-19 pandemic and pregnancy. Obstetrics and Gynaecology Research. 2020;46(10):1958-66.

Pitones RV, Chávez CE, Hurtado CA, González RA, Serafín HN. Is periodontal disease a risk factor for severe COVID-19 illness? 2020;144:109969.

Hantoushzadeh S, Shamshirsaz AA, Aleyasin A, Seferovic MD, Aski SK, Arian SE, et al. Maternal death due to COVID-19. Am J Obstet Gynecol. 2020;223(1):109 e1- e16.

Panagiotakopoulos L, Myers TR, Gee J, Lipkind HS, Kharbanda EO, Ryan DS, et al. SARS-CoV-2 Infection Among Hospitalized Pregnant Women: Reasons for Admission and Pregnancy Characteristics. CDC. 2020;69(38):1355-9.

Thompson LJ, Nguyer ML, Noble NK, Aronoff MD. COVID-19-related disease severity in pregnancy. Am J Reprod Immunol. 2020;84:13339.

Novoa RH, Quintana W, Llancarí P, Urbina-Quispe K, Guevara-Ríos E, Ventura W. Maternal clinical characteristics and perinatal outcomes among pregnant women with coronavirus disease 2019. A systematic review. Travel Med Infect Dis. 2020;39:101919.

Barbero P, Muguerza L, Herraiz I, García BA, San Juan R, Forcén L. SARS-CoV-2 in pregnancy: characteristics and outcomes of hospitalized and non-hospitalized women due to COVID-19. J Matern Fetal Neonatal Med. 2020;34(4):30951-7.

Boushra MN, Koyfman A, Long B. COVID-19 in pregnancy and the puerperium: A review for emergency physicians. Am J Emerg Med. 2020;20(30951):735-6757.

Published
2021-12-05
How to Cite
López-Rodríguez, G., Galván, M., Montiel Hernández, R. A., & Alvarez, J. (2021). Risks due to COVID-19 during pregnancy, the effect of maternal obesity. Educación Y Salud Boletín Científico Instituto De Ciencias De La Salud Universidad Autónoma Del Estado De Hidalgo, 10(19), 38-41. https://doi.org/10.29057/icsa.v10i19.7185

Most read articles by the same author(s)