Hydrolysis of esters and dialkyl malonates mediated by t-BuNH2/LiBr/alcohol/H2O

Palabras clave: Hidrólisis de ésteres, monohidrólisis, malonatos de dialquilo, t-BuNH2/LiBr/MeOH/H2O

Resumen

Se describe una metodología eficiente y sencilla para la hidrólisis de ésteres y monohidrólisis de malonatos de dialquilo con el uso de t-BuNH2/MeOH/H2O con y sin LiBr. El método es de aplicación general debido a que los ésteres de Me, Et, i-Pr, t-Bu, Bn y alilo se hidrolizan adecuadamente para dar los ácidos carboxílicos correspondientes en excelentes rendimientos. El alcance del procedimiento se exploró para la desprotección de monoésteres alifáticos, aromáticos e insaturados, así como de malonatos de dialquilo. Las reacciones son, en general, muy limpias, dan rendimientos altos y no se obtienen subproductos. La selectividad del método se demostró mediante la hidrólisis de ésteres en presencia de un grupo protector N-Boc.

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Publicado
2020-11-02
Cómo citar
Maldonado-Ortega, U., Trejo-Carbajal , N., Fragoso-Vázquez, M. J., Sánchez-Zavala, M., Meléndez-Rodríguez, M., & Suárez-Castillo, O. R. (2020). Hydrolysis of esters and dialkyl malonates mediated by t-BuNH2/LiBr/alcohol/H2O. Pädi Boletín Científico De Ciencias Básicas E Ingenierías Del ICBI, 8(16), 119-125. https://doi.org/10.29057/icbi.v8i16.6460