Revisión de la Hidroxiapatita Nanoestructurada como Alternativa para Tratamiento de Cáncer

Palabras clave: Hidroxiapatita, Hidroxiapatita dopada, Funcionalización, Toxicidad, Liberación de fármacos, Tratamiento de Cáncer

Resumen

La hidroxiapatita nanoestructurada (nano-Hap) surge como una potente herramienta biomimética para mejorar el desempeño de las terapias convencionales contra el cáncer. Su composición química, textura y capacidad de dopaje, así como su compatibilidad, estabilidad y actividad en sistemas biológicos la hacen una candidata excepcional para el desarrollo de vehículos para la entrega selectiva de fármacos antineoplásicos. La presente revisión va dirigida a estudiantes e investigadores del área de materiales avanzados, con la intensión de introducirlos en la importancia de explorar de manera interdisciplinaria las propiedades intrínsecas y adquiridas de los nanomateriales en beneficio de la sociedad, principalmente para ciencias de la salud. Con un propósito formativo, presentamos generalidades de la síntesis, caracterización y evaluación toxicológica in vitro de la nano-Hap para, finalmente discutir los avances más relevantes en el área del 2016 a la fecha. Concluimos incentivando a la comunidad al trabajo colaborativo interdisciplinar para innovar en Nanomedicina con materiales que permitan mejorar el desempeño de los protocolos oncológicos existentes.

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Agrawal, Shital, Madhura Kelkar, Abhijit De, Ajit R. Kulkarni, and Mayuri N. Gandhi. 2018. “Newly Emerging Mesoporous Strontium Hydroxyapatite Nanorods: Microwave Synthesis and Relevance as Doxorubicin Nanocarrier.” Journal of Nanoparticle Research 20 (9): 1–11. https://doi.org/10.1007/s11051-018-4335-y.

Barbanente, Alessandra, Robin A. Nadar, Lorenzo Degli Esposti, Barbara Palazzo, Michele Iafisco, Jeroen J.J.P. Van Den Beucken, Sander C.G. Leeuwenburgh, and Nicola Margiotta. 2020. “Platinum-Loaded, Selenium-Doped Hydroxyapatite Nanoparticles Selectively Reduce Proliferation of Prostate and Breast Cancer Cells Co-Cultured in the Presence of Stem Cells.” Journal of Materials Chemistry B 8 (14): 2792–2804. https://doi.org/10.1039/d0tb00390e.

Cheang, Tuck Yun, Yi Yan Lei, Zhan Qiang Zhang, Hong Yan Zhou, Run Yi Ye, Ying Lin, and Shenming Wang. 2018. “Graphene Oxide–Hydroxyapatite Nanocomposites Effectively Deliver HSV-TK Suicide Gene to Inhibit Human Breast Cancer Growth.” Journal of Biomaterials Applications 33 (2): 216–26. https://doi.org/10.1177/0885328218788242.

Clemons, Tristan D., Ruhani Singh, Anabel Sorolla, Nutan Chaudhari, Alysia Hubbard, and K. Swaminatha Iyer. 2018. “Distinction between Active and Passive Targeting of Nanoparticles Dictate Their Overall Therapeutic Efficacy.” Langmuir 34 (50): 15343–49. https://doi.org/10.1021/acs.langmuir.8b02946.

Couvreur, P., B. Kante, L. Grislain, M. Roland, and P. Speiser. 1982. “Toxicity of Polyalkylcyanoacrylate Nanoparticles II: Doxorubicin-Loaded Nanoparticles.” Journal of Pharmaceutical Sciences 71 (7): 790–92. https://doi.org/10.1002/jps.2600710717.

Cui, Xinhui, Tong Liang, Changsheng Liu, Yuan Yuan, and Jiangchao Qian. 2016. “Correlation of Particle Properties with Cytotoxicity and Cellular Uptake of Hydroxyapatite Nanoparticles in Human Gastric Cancer Cells.” Materials Science and Engineering: C 67 (October): 453–60. https://doi.org/10.1016/j.msec.2016.05.034.

El-Bassyouni, Gehan T., Samah S. Eldera, Sayed H. Kenawy, and Esmat M.A. Hamzawy. 2020. “Hydroxyapatite Nanoparticles Derived from Mussel Shells for in Vitro Cytotoxicity Test and Cell Viability.” Heliyon 6 (6): e04085. https://doi.org/10.1016/j.heliyon.2020.e04085.

Ficai, Anton, Catarina MARQUES, José M.F. FERREIRA, Ecaterina Andronescu, Denisa FICAI, and Maria Sonmez. 2014. “Multifunctional Materials for Bone Cancer Treatment.” International Journal of Nanomedicine 9 (May): 2713. https://doi.org/10.2147/ijn.s55943.

Huang, Hui, Wei Feng, Yu Chen, and Jianlin Shi. 2020. “Inorganic Nanoparticles in Clinical Trials and Translations.” Nano Today 35. https://doi.org/10.1016/j.nantod.2020.100972.

Ignjatović, Nenad L., Marija Sakač, Ivana Kuzminac, Vesna Kojić, Smilja Marković, Dana Vasiljević-Radović, Victoria M. Wu, Vuk Uskoković, and Dragan P. Uskoković. 2018. “Chitosan Oligosaccharide Lactate Coated Hydroxyapatite Nanoparticles as a Vehicle for the Delivery of Steroid Drugs and the Targeting of Breast Cancer Cells.” Journal of Materials Chemistry B 6 (43): 6957–68. https://doi.org/10.1039/c8tb01995a.

Izadi, Azadeh, Azadeh Meshkini, and Mohammad H. Entezari. 2019. “Mesoporous Superparamagnetic Hydroxyapatite Nanocomposite: A Multifunctional Platform for Synergistic Targeted Chemo-Magnetotherapy.” Materials Science and Engineering: C 101 (August): 27–41. https://doi.org/10.1016/j.msec.2019.03.066.

Khan, Suliman, Muhammad Wajid Ullah, Rabeea Siddique, Yang Liu, Ismat Ullah, Mengzhou Xue, Guang Yang, and Hongwei Hou. 2019. “Catechins-Modified Selenium-Doped Hydroxyapatite Nanomaterials for Improved Osteosarcoma Therapy Through Generation of Reactive Oxygen Species.” Frontiers in Oncology 9 (JUN): 499. https://doi.org/10.3389/fonc.2019.00499.

Lelli, Marco, Norberto Roveri, Cristina Marzano, James D Hoeschele, Alessandra Curci, Nicola Margiotta, Valentina Gandin, and Giovanni Natile. 2016. “Hydroxyapatite Nanocrystals as a Smart, PH Sensitive, Delivery System for Kiteplatin” 45: 13187. https://doi.org/10.1039/c6dt01976e.

Li, Li, Haihua Pan, Jinhui Tao, Xurong Xu, Caiyun Mao, Xinhua Gu, and Ruikang Tang. 2008. “Repair of Enamel by Using Hydroxyapatite Nanoparticles as the Building Blocks.” Journal of Materials Chemistry 18 (34): 4079–84. https://doi.org/10.1039/b806090h.

Liu, Ying, Yuxia Tang, Ying Tian, Jiang Wu, Jing Sun, Zhaogang Teng, Shouju Wang, and Guangming Lu. 2019. “Gadolinium-Doped Hydroxyapatite Nanorods as T1 Contrast Agents and Drug Carriers for Breast Cancer Therapy.” ACS Applied Nano Materials 2 (3): 1194–1201. https://doi.org/10.1021/acsanm.8b02036.

Maia, Ana Luiza Chaves, Carolina de Aguiar Ferreira, André Luis Branco de Barros, Aline Teixeira Maciel e Silva, Gilson Andrade Ramaldes, Armando da Silva Cunha Júnior, Diogo Coelho de Pádua Oliveira, Christian Fernandes, and Daniel Crístian Ferreira Soares. 2018. “Vincristine-Loaded Hydroxyapatite Nanoparticles as a Potential Delivery System for Bone Cancer Therapy.” Journal of Drug Targeting 26 (7): 592–603. https://doi.org/10.1080/1061186X.2017.1401078.

Mendoza-Anaya, D., E. Flores-Díaz, G. Mondragón-Galicia, M. E. Fernández-García, E. Salinas-Rodríguez, T. V.K. Karthik, and V. Rodríguez-Lugo. 2018. “The Role of Eu on the Thermoluminescence Induced by Gamma Radiation in Nano Hydroxyapatite.” Journal of Materials Science: Materials in Electronics 29 (18): 15579–86. https://doi.org/10.1007/s10854-018-9147-4.

Olszta, Matthew J., Xingguo Cheng, Sang Soo Jee, Rajendra Kumar, Yi Yeoun Kim, Michael J. Kaufman, Elliot P. Douglas, and Laurie B. Gower. 2007. “Bone Structure and Formation: A New Perspective.” Materials Science and Engineering R: Reports. Elsevier. https://doi.org/10.1016/j.mser.2007.05.001.

Orooji, Yasin, Sobhan Mortazavi-Derazkola, Seyedeh Masoumeh Ghoreishi, Mahnaz Amiri, and Masoud Salavati-Niasari. 2020. “Mesopourous Fe3O4@SiO2-Hydroxyapatite Nanocomposite: Green Sonochemical Synthesis Using Strawberry Fruit Extract as a Capping Agent, Characterization and Their Application in Sulfasalazine Delivery and Cytotoxicity.” Journal of Hazardous Materials 400 (December): 123140. https://doi.org/10.1016/j.jhazmat.2020.123140.

Ortiz, S. Lopez, J. Hernandez Avila, M. P. Gutierrez, Heberte Gomez-Pozos, T. V.K. Karthik, and V. Rodriguez Lugo. 2017. “Hydrothermal Synthesis and Characterization of Hydroxyapatite Microstructures.” 2017 14th International Conference on Electrical Engineering, Computing Science and Automatic Control, CCE 2017, 0–3. https://doi.org/10.1109/ICEEE.2017.8108902.

Pernal, Sebastian, Victoria M. Wu, and Vuk Uskoković. 2017. “Hydroxyapatite as a Vehicle for the Selective Effect of Superparamagnetic Iron Oxide Nanoparticles against Human Glioblastoma Cells.” ACS Applied Materials and Interfaces 9 (45): 39283–302. https://doi.org/10.1021/acsami.7b15116.

Prasad, S. Ram, A. Jayakrishnan, and T. S.Sampath Kumar. 2020. “Combinational Delivery of Anticancer Drugs for Osteosarcoma Treatment Using Electrosprayed Core Shell Nanocarriers.” Journal of Materials Science: Materials in Medicine 31 (5): 1–11. https://doi.org/10.1007/s10856-020-06379-5.

Ribeiro, Tiago P., Fernando J. Monteiro, and Marta S. Laranjeira. 2020. “Duality of Iron (III) Doped Nano Hydroxyapatite in Triple Negative Breast Cancer Monitoring and as a Drug-Free Therapeutic Agent.” Ceramics International 46 (10): 16590–97. https://doi.org/10.1016/j.ceramint.2020.03.231.

Rodríguez-Lugo, V., T. V.K. Karthik, D. Mendoza-Anaya, E. Rubio-Rosas, L. S. Villaseñor Cerón, M. I. Reyes-Valderrama, and E. Salinas-Rodríguez. 2018. “Wet Chemical Synthesis of Nanocrystalline Hydroxyapatite Flakes: Effect of PH and Sintering Temperature on Structural and Morphological Properties.” Royal Society Open Science 5 (8). https://doi.org/10.1098/rsos.180962.

Rodríguez Lugo, V., V. M. Castaño, and E. Rubio-Rosas. 2016. “Biomimetic Growth of Hydroxylapatite on SiO2–PMMA Hybrid Coatings.” Materials Letters 184: 265–68. https://doi.org/10.1016/j.matlet.2016.08.068.

Sadat-Shojai, Mehdi, Mohammad Taghi Khorasani, Ehsan Dinpanah-Khoshdargi, and Ahmad Jamshidi. 2013. “Synthesis Methods for Nanosized Hydroxyapatite with Diverse Structures.” Acta Biomaterialia 9 (8): 7591–7621.

https://doi.org/10.1016/j.actbio.2013.04.012.

Sánchez-Campos, D., D. Mendoza-Anaya, M. I. Reyes-Valderrama, S. Esteban-Gómez, and V. Rodríguez-Lugo. 2020. “Cationic Surfactant at High PH in Microwave HAp Synthesis.” Materials Letters 265 (April): 127416. https://doi.org/10.1016/j.matlet.2020.127416.

Selvaraju, Sharmila, Sathya Ramalingam, and Jonnalagadda Raghava Rao. 2018. “Inorganic Apatite Nanomaterial: Modified Surface Phenomena and Its Role in Developing Collagen Based Polymeric Bio-Composite (Coll-PLGA/HAp) for Biological Applications.” Colloids and Surfaces B: Biointerfaces 172 (December): 734–42. https://doi.org/10.1016/j.colsurfb.2018.09.038.

Singh, Gurdyal, Ravinder Pal Singh, and Sukhwinder Singh Jolly. 2020. “Customized Hydroxyapatites for Bone-Tissue Engineering and Drug Delivery Applications: A Review.” Journal of Sol-Gel Science and Technology. Springer. https://doi.org/10.1007/s10971-020-05222-1.

Szcześ, Aleksandra, Lucyna Hołysz, and Emil Chibowski. 2017. “Synthesis of Hydroxyapatite for Biomedical Applications.” Advances in Colloid and Interface Science 249 (April): 321–30. https://doi.org/10.1016/j.cis.2017.04.007.

Veerla, Sarath Chandra, Da Reum Kim, Jongjun Kim, Honglae Sohn, and Sung Yun Yang. 2019. “Controlled Nanoparticle Synthesis of Ag/Fe Co-Doped Hydroxyapatite System for Cancer Cell Treatment.” Materials Science and Engineering C 98 (January): 311–23. https://doi.org/10.1016/j.msec.2018.12.148.

Verma, Gunjan, Neena G. Shetake, Shruti Pandrekar, B. N. Pandey, P. A. Hassan, and K. I. Priyadarsini. 2020. “Development of Surface Functionalized Hydroxyapatite Nanoparticles for Enhanced Specificity towards Tumor Cells.” European Journal of Pharmaceutical Sciences 144 (December 2019): 105206. https://doi.org/10.1016/j.ejps.2019.105206.

Villaseñór-Cerón, Lesly Sabina, Demetrio Mendoza-Anaya, María Isabel Reyes-Valderrama, Eleazar Salinas Rodríguez, and Ventura Rodríguez-Lugo. 2019. “Estudio Termodinámico Para La Obtención de Nanohidroxiapatita Por El Método de Microondas.” Pädi Boletín Científico de Ciencias Básicas e Ingenierías Del ICBI 7 (13): 35–40. https://doi.org/10.29057/icbi.v7i13.4131.

Villaseñor Cerón, L. S., V. Rodríguez Lugo, J. A. Arenas Alatorre, M. E. Fernández-Garcia, M. I. Reyes-Valderrama, P. González-Martínez, and D. Mendoza Anaya. 2019. “Characterization of Hap Nanostructures Doped with AgNp and the Gamma Radiation Effects.” Results in Physics 15 (September): 102702. https://doi.org/10.1016/j.rinp.2019.102702.

Wang, Yanhua, Na Qin, Caifa Zhao, Jiehua Yuan, Shiqi Lu, Wenjing Li, Huiyao Xiang, and Hang Hao. 2019. “The Correlation between the Methylation of PTEN Gene and the Apoptosis of Osteosarcoma Cells Mediated by SeHA Nanoparticles.” Colloids and Surfaces B: Biointerfaces 184 (December): 110499. https://doi.org/10.1016/j.colsurfb.2019.110499.

Wang, Yifan, Jianglin Wang, Hang Hao, Mingle Cai, Shiyao Wang, Jun Ma, Yan Li, Chuanbin Mao, and Shengmin Zhang. 2016. “In Vitro and in Vivo Mechanism of Bone Tumor Inhibition by Selenium-Doped Bone Mineral Nanoparticles.” ACS Nano 10 (11): 9927–37. https://doi.org/10.1021/acsnano.6b03835.

Weerasuriya, D.R.K., W.P.S.L. Wijesinghe, and R.M.G. Rajapakse. 2017. “Encapsulation of Anticancer Drug Copper Bis(8-Hydroxyquinoline) in Hydroxyapatite for PH-Sensitive Targeted Delivery and Slow Release.” Materials Science and Engineering: C 71 (February): 206–13. https://doi.org/10.1016/j.msec.2016.10.010.

Wu, Zihan, Xiaoyu Ma, Yifan Ma, Zhaogang Yang, Yuan Yuan, and Changsheng Liu. 2020. “Core/Shell PEGS/HA Hybrid Nanoparticle Via Micelle-Coordinated Mineralization for Tumor-Specific Therapy.” ACS Applied Materials and Interfaces 12 (10): 12109–19. https://doi.org/10.1021/acsami.0c00068.

Xiaoyu, Ma, Dong Xiuling, Zang Chunyu, Sun Yi, Qian Jiangchao, Yuan Yuan, and Liu Changsheng. 2019. “Polyglutamic Acid-Coordinated Assembly of Hydroxyapatite Nanoparticles for Synergistic Tumor-Specific Therapy.” Nanoscale 11 (32): 15312–25. https://doi.org/10.1039/c9nr03176f.

Xiong, Hui, Shi Du, Jiang Ni, Jianping Zhou, and Jing Yao. 2016. “Mitochondria and Nuclei Dual-Targeted Heterogeneous Hydroxyapatite Nanoparticles for Enhancing Therapeutic Efficacy of Doxorubicin.” Biomaterials 94 (July): 70–83. https://doi.org/10.1016/j.biomaterials.2016.04.004.

Xiong, Hui, Shi Du, Ping Zhang, Zhijie Jiang, Jianping Zhou, and Jing Yao. 2018. “Primary Tumor and Pre-Metastatic Niches Co-Targeting ‘Peptides-Lego’ Hybrid Hydroxyapatite Nanoparticles for Metastatic Breast Cancer Treatment.” Biomaterials Science 6 (10): 2591–2604. https://doi.org/10.1039/c8bm00706c.

Yanhua, Wang, Hang Hao, Yan Li, and Shengmin Zhang. 2016. Selenium-Substituted Hydroxyapatite Nanoparticles and Their in Vivo Antitumor Effect on Hepatocellular Carcinoma. Colloids and Surfaces B: Biointerfaces. Vol. 140. Elsevier B.V. https://doi.org/10.1016/j.colsurfb.2015.12.056.

Zhao, Lina, Wenhui Zhao, Ye Liu, Xue Chen, and Yan Wang. 2017. “Nano-Hydroxyapatite-Derived Drug and Gene Co-Delivery System for Anti-Angiogenesis Therapy of Breast Cancer.” Medical Science Monitor 23 (October): 4723–32. https://doi.org/10.12659/MSM.902538.

Publicado
2020-12-12
Cómo citar
Rodríguez-Lugo, V., Salado-Leza, D. E., López Ortiz, S., Mendoza-Anaya, D., Villaseñor-Cerón, L. S., & Reyes-Valderrama, M. I. (2020). Revisión de la Hidroxiapatita Nanoestructurada como Alternativa para Tratamiento de Cáncer. Pädi Boletín Científico De Ciencias Básicas E Ingenierías Del ICBI, 8(Especial), 115-127. https://doi.org/10.29057/icbi.v8iEspecial.6466

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