Microesferas de Alginato-TiO2 como sistemas de dosificación de curcumina

José Reyes Cortés-Montelongo; María Cristina Ibarra-Alonso; Antonia Martínez-Luévanos; Rosa Idalia Narro-Céspedes; Catalina María Pérez-Berume

doi:10.29057/icbi.v9iEspecial2.7979

José Reyes Cortés-Montelongo Universidad Autónoma de Coahuila https://orcid.org/0000-0002-7237-8913
María Cristina Ibarra-Alonso Universidad Autónoma de Coahuila https://orcid.org/0000-0002-5719-8164
Antonia Martínez-Luévanos Universidad Autónoma de Coahuila https://orcid.org/0000-0003-3499-1693
Rosa Idalia Narro-Céspedes Universidad Autónoma de Coahuila https://orcid.org/0000-0002-3559-1520
Catalina María Pérez-Berume Universidad Autónoma de Coahuila https://orcid.org/0000-0002-2836-010X

DOI: https://doi.org/10.29057/icbi.v9iEspecial2.7979

Palabras clave: Alginato, Curcumina, Dióxido de Titanio, Micro-esferas y sistemas de liberación

Resumen

Los sistemas de liberación controlada están en creciente desarrollo, debido a la necesidad que existe en conseguir una dosificación óptima, en el lugar adecuado y el control de esta dosificación por periodos lagos. La curcumina ha demostrado diversas acciones biológicas, principalmente como antioxidante, anticancerígeno y antibacteriano. Por otro lado, el óxido de titanio (TiO2) y el Alginato (Alg), son ampliamente utilizados en la biomedicina como portadores de sustancias activas. En este trabajo se sintetizaron micro-esferas de alginato, que contenían oxido de titanio cargados con curcumina. El biomaterial resultante mostro una morfología esférica. La técnica FTIR-ATR demostró la formación del biomaterial, TGA se utilizó para determinar la estabilidad térmica de las esferas. También, se evalúo las la biocompatibilidad in vitro, resultando que las esferas Alg/TiO2-Cur no presentaban toxicidad en eritrocitos humanos. Finalmente se evaluó a la liberación de curcumina. Por tanto, las esferas de Alg/TiO2-Cur resultaron ser biocompatibles y se pueden utilizar como eficientes vehículos para la liberación de curcumina

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