Microesferas de Alginato-TiO2 como sistemas de dosificación de curcumina

Palabras clave: Alginato, Curcumina, Dióxido de Titanio, Micro-esferas y sistemas de liberación

Resumen

Los sistemas de liberación controlada están en creciente desarrollo, debido a la necesidad que existe en conseguir una dosificación óptima, en el lugar adecuado y el control de esta dosificación por periodos lagos. La curcumina ha demostrado diversas acciones biológicas, principalmente como antioxidante, anticancerígeno y antibacteriano. Por otro lado, el óxido de titanio (TiO2) y el Alginato (Alg), son ampliamente utilizados en la biomedicina como portadores de sustancias activas. En este trabajo se sintetizaron micro-esferas de alginato, que contenían oxido de titanio cargados con curcumina. El biomaterial resultante mostro una morfología esférica. La técnica FTIR-ATR demostró la formación del biomaterial, TGA se utilizó para determinar la estabilidad térmica de las esferas. También, se evalúo las la biocompatibilidad in vitro, resultando que las esferas Alg/TiO2-Cur no presentaban toxicidad en eritrocitos humanos. Finalmente se evaluó a la liberación de curcumina. Por tanto, las esferas de Alg/TiO2-Cur resultaron ser biocompatibles y se pueden utilizar como eficientes vehículos para la liberación de curcumina

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Publicado
2021-12-12
Cómo citar
Cortés-Montelongo, J. R., Ibarra-Alonso, M. C., Martínez-Luévanos , A., Narro-Céspedes , R. I., & Pérez-Berume, C. M. (2021). Microesferas de Alginato-TiO2 como sistemas de dosificación de curcumina. Pädi Boletín Científico De Ciencias Básicas E Ingenierías Del ICBI, 9(Especial2), 139-144. https://doi.org/10.29057/icbi.v9iEspecial2.7979
Tipo de manuscrito
Artículos de investigación