Importance of pharmacokinetics in clinical practice
Abstract
Pharmacokinetics is the study of the temporal evolution of the concentrations of a drug and/or its metabolites in an organism (fluids, tissues, and extracorporeal compartments) and the mathematical relationships that allow interpreting the data through defined models. It is the study of the ADME process (absorption, distribution, metabolism and excretion) that a drug undergoes once administered to an individual. In addition, pharmacokinetics is an important aspect of drug therapy and diagnosis of organ function. If an estimate of the changes that influence the therapy, with drugs that have a wide therapeutic range were made, it would be observed that it is very likely that they will cause no harm; however, for drugs with a narrow therapeutic margin, it is recommended to carry out a control, through the measurement of its concentrations and possibly, the correction of the therapy regimen, particularly if side effects occur when the toxic limit is exceeded.
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Khojasteh SC, Wong H, Hop CE. ADME Properties and Their Dependence on Physicochemical Properties. Drug Metabolism and Pharmacokinetics Quick Guide. 2011: 165-181.
Urso R, Blardi P, Giorgi G. A short introduction to pharmacokinetics. Eur Rev Med Pharmacol Sci 2002; 6(2-3): 33-44.
Yates JW, Arundel PA. On the volume of distribution at steady state and its relationship with two-compartmental models. J Pharm Sci 2008; 97(1): 111-22.
Dorne JL. Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation. Fundam Clin Pharmacol 2004; 18(6): 609-20.
Guk J, Lee SG, Chae D, Kim JH, Park K. Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly. J Pharm Sci 2019; 108(8): 2765-2773.
Dang MT, Hambleton J, Kayser SR. The influence of ethnicity on warfarin dosage requirement. Ann Pharmacother 2005; 39(6): 1008-12.
Hanratty CG, McGlinchey P, Johnston GD, Passmore AP. Differential pharmacokinetics of digoxin in elderly patients. Drugs Aging 2000; 17(5): 353-62.
Aronson JK, Hardman M. ABC of monitoring drug therapy. Measuring plasma drug concentrations. BMJ 1992; 305(6861):1078-80.
