Pharmacokinetics, Pharmacogenomics and Interindividual variability
Abstract
Pharmacokinetics can be defined as the “relationship between the administered dose and the plasma drug concentration”, and implies the study of the absorption, distribution, metabolism and excretion processes. Pharmacokinetic modifications help to explain the different responses that occur between different subjects, giving interindividual variability, at the same time, the pharmacokinetic approach to define interindividual variability in response to drugs needs a genetic explanation to understand it. Pharmacogenetics studies the genetic causes of individual DNA variations in drug response, and pharmacogenomics evaluate a genome-wide analysis (DNA, RNA level) of the genetic determinants of drug efficacy and toxicity.
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