Hidrólisis de ésteres y malonatos de dialquilo con t-BuNH2/LiBr/alcohol/H2O
Abstract
An efficient, simple protocol for the ester hydrolysis and monohydrolysis of dialkyl malonates by t-BuNH2/MeOH/H2O with or without LiBr is described. The method is of general applicability since alkyl esters including Me, Et, i-Pr, t-Bu, Bn and allyl esters have been successfully cleaved to give the free carboxylic acids in excellent yields. The scope of the procedure was explored for the deprotection of a series of aliphatic, aromatic, unsaturated monoesters and dialkylmalonates. The reactions are, in general, very clean giving very high yields, and no side products have been isolated. The selectivity of the method was demonstrated by the hydrolysis of esters in the presence of an N-Boc protecting group.
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