Genotoxic evaluation of a novel nanohybrid for delivery of bioactive molecules
Abstract
In the last two decades, organic-inorganic hybrid nanomaterials have reached an intensive development. However, before their possible application, a complete and adequate evaluation of their physicochemical properties, and benefits is required, as well of their potential toxic effects for human health. Therefore, this study aimed to determine the possible in vivo genotoxic effect of nanohybrids designed based on layered double hydroxides/ß-hydroxy-ß-methylbutyrate/collagen (ZnAl/HMB/Col) after acute oral exposure. The genotoxic potential was evaluated in 9-week-old male Sprague-Dawley (SD) rats after 7 continuous days of oral exposure to the nanohybrids at dose of 2,000 mg/kg. No statistically significant difference was observed between the number of micronuclei (MN) and the administration of the treatments over the values of the control group.
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