Microbiota intestinal y su relación con la salud mental. Una revisión narrativa
Resumen
En las últimas décadas la prevalencia de los trastornos mentales ha incrementado de manera global. A pesar de que también han existido avances en las terapias farmacológicas, la prevención y el manejo de este tipo de enfermedades continúan siendo un reto para la salud pública. Diversa evidencia sugiere que la microbiota intestinal ejerce una influencia considerable en la neurofisiología humana por lo que las interacciones entre la microbiología intestinal y los diversos procesos metabólicos y fisiológicos del huésped ahora se han implicado tanto en el desarrollo de afecciones psiquiátricas como en la eficacia de muchas terapias comunes. Es imperativo que el personal de salud que tienen un trato directo con personas que padecen problemas de salud mental, conozcan el efecto de la disbiosis de la microbiota intestinal sobre el desarrollo de enfermedades mentales, así como el mecanismo subyacente de dicha relación, para poder emprender estrategias para su tratamiento y prevención. Por tal motivo, este manuscrito presenta una revisión narrativa sobre la evidencia experimental y epidemiológica que vincula al microbiota intestinal con la presencia de ansiedad, depresión, trastorno obsesivo compulsivo, trastorno del espectro autista y demencia.
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[l] Bander Z, Nitert MD, Mousa A, Naderpoor N. The Gut Microbiota and Inflammation: An Overview. Int J Environ Res Public Health. 2020;17(20):7618. doi:10.3390/ijerph17207618
de Vos WM, Tilg H, Van Hul M, Cani PD. Gut microbiome and health: mechanistic insights. Gut. 2022;71(5):1020-1032. doi:10.1136/gutjnl-2021-326789
Belizário JE, Faintuch J. Microbiome and Gut Dysbiosis. Exp Suppl 2012. 2018;109:459-476. doi:10.1007/978-3-319-74932-7_13
Vivarelli S, Salemi R, Candido S, et al. Gut Microbiota and Cancer: From Pathogenesis to Therapy. Cancers. 2019;11(1):38. doi:10.3390/cancers11010038
Liu Y, Wang J, Wu C. Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics. Front Nutr. 2021;8:634897. doi:10.3389/fnut.2021.634897
Wang PX, Deng XR, Zhang CH, Yuan HJ. Gut microbiota and metabolic syndrome. Chin Med J (Engl). 2020;133(7):808-816. doi:10.1097/CM9.0000000000000696
Andrioaie IM, Duhaniuc A, Nastase EV, et al. The Role of the Gut Microbiome in Psychiatric Disorders. Microorganisms. 2022;10(12):2436. doi:10.3390/microorganisms10122436
. Halverson T, Alagiakrishnan K. Gut microbes in neurocognitive and mental health disorders. Ann Med. 52(8):423-443. doi:10.1080/07853890.2020.1808239
Meaddough E, Abenavoli L, Sarasua S, Boccuto L. Genetic and environmental factors influencing the interaction between the gut microbiota and the human host: implications for gastrointestinal disorders and treatment approaches. Minerva Gastroenterol. 2021;67(4):369-376. doi:10.23736/S2724-5985.21.02927-2
Royet J, Gupta D, Dziarski R. Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nat Rev Immunol. 2011;11(12):837-851. doi:10.1038/nri3089
.Saraf MK, Piccolo BD, Bowlin AK, et al. Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon. Microbiome. 2017;5(1):77. doi:10.1186/s40168-017-0297-z
Kaur H, Bose C, Mande SS. Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis. Front Neurosci. 2019;13:1365. doi:10.3389/fnins.2019.01365
Rea K, Dinan TG, Cryan JF. Gut Microbiota: A Perspective for Psychiatrists. Neuropsychobiology. 2020;79(1):50-62. doi:10.1159/000504495
Russell WR, Hoyles L, Flint HJ, Dumas ME. Colonic bacterial metabolites and human health. Curr Opin Microbiol. 2013;16(3):246-254. doi:10.1016/j.mib.2013.07.002
Cummings JH, Macfarlane GT. Role of intestinal bacteria in nutrient metabolism. JPEN J Parenter Enteral Nutr. 1997;21(6):357-365. doi:10.1177/0148607197021006357
Wu T, Rayner CK, Young RL, Horowitz M. Gut motility and enteroendocrine secretion. Curr Opin Pharmacol. 2013;13(6):928-934. doi:10.1016/j.coph.2013.09.002
Gribble FM, Reimann F. Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium. Annu Rev Physiol. 2016;78:277-299. doi:10.1146/annurev-physiol-021115-105439
Mayer EA. Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci. 2011;12(8):453-466. doi:10.1038/nrn3071
Fontané L, Benaiges D, Goday A, Llauradó G, Pedro-Botet J. Influencia de la microbiota y de los probióticos en la obesidad. Clínica E Investig En Arterioscler. 2018;30(6):271-279. doi:10.1016/j.arteri.2018.03.004
Proceedings of the International Symposium on Probiotics and Prebiotics. Kiel, Germany, June 11-12, 1998. Am J Clin Nutr. 2001;73(2 Suppl):361S-498S. doi:10.1093/ajcn/73.2.361s
Rondon L, Añez Zavala M, Salvatierra Hidalgo A, Meneses Barrios RT, Heredia Rodriguez MT. Probióticos: generalidades. Arch Venez Pueric Pediatría. 2015;78(4):123-128.
Dean E. Anxiety. Nurs Stand R Coll Nurs G B 1987. 2016;30(46):15. doi:10.7748/ns.30.46.15.s17
Organización Mundial de la Salud. Trastornos mentales. Published 2022. Accessed September 12, 2023. https://www.who.int/es/news-room/fact-sheets/detail/mental-disorders
O’Malley D, Julio-Pieper M, Gibney SM, Dinan TG, Cryan JF. Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour. Stress Amst Neth. 2010;13(2):114-122. doi:10.3109/10253890903067418
Jin X, Zhang Y, Celniker SE, et al. Gut microbiome partially mediates and coordinates the effects of genetics on anxiety-like behavior in Collaborative Cross mice. Sci Rep. 2021;11(1):270. doi:10.1038/s41598-020-79538-x
Collins SM, Kassam Z, Bercik P. The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications. Curr Opin Microbiol. 2013;16(3):240-245. doi:10.1016/j.mib.2013.06.004
El Aidy S, Ramsteijn AS, Dini-Andreote F, et al. Serotonin Transporter Genotype Modulates the Gut Microbiota Composition in Young Rats, an Effect Augmented by Early Life Stress. Front Cell Neurosci. 2017;11:222. doi:10.3389/fncel.2017.00222
Eskandarzadeh S, Effatpanah M, Khosravi-Darani K, et al. Efficacy of a multispecies probiotic as adjunctive therapy in generalized anxiety disorder: a double blind, randomized, placebo-controlled trial. Nutr Neurosci. 2021;24(2):102-108. doi:10.1080/1028415X.2019.1598669
Malhi GS, Mann JJ. Depression. Lancet Lond Engl. 2018;392(10161):2299-2312. doi:10.1016/S0140-6736(18)31948-2
Organización Mundial de la Salud. Depresión. Accessed September 12, 2023. https://www.who.int/es/news-room/fact-sheets/detail/depression
Kelly JR, Borre Y, O’ Brien C, et al. Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. J Psychiatr Res. 2016;82:109-118. doi:10.1016/j.jpsychires.2016.07.019
Bastiaanssen TFS, Cussotto S, Claesson MJ, Clarke G, Dinan TG, Cryan JF. Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder. Harv Rev Psychiatry. 2020;28(1):26-39. doi:10.1097/HRP.0000000000000243
Jaacks LM, Yadav S, Panuwet P, et al. Metabolite of the pesticide DDT and incident type 2 diabetes in urban India. Environ Int. 2019;133:105089. doi:10.1016/j.envint.2019.105089
Garcia-Mantrana I, Selma-Royo M, Alcantara C, Collado MC. Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population. Front Microbiol. 2018;9:890. doi:10.3389/fmicb.2018.00890
Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. Nutr Burbank Los Angel Cty Calif. 2016;32(3):315-320. doi:10.1016/j.nut.2015.09.003
Brock H, Hany M. Obsessive-Compulsive Disorder. In: StatPearls. StatPearls Publishing; 2023. Accessed September 12, 2023. http://www.ncbi.nlm.nih.gov/books/NBK553162/
Yano JM, Yu K, Donaldson GP, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161(2):264-276. doi:10.1016/j.cell.2015.02.047
Rao NP, Venkatasubramanian G, Ravi V, Kalmady S, Cherian A, Yc JR. Plasma cytokine abnormalities in drug-naïve, comorbidity-free obsessive-compulsive disorder. Psychiatry Res. 2015;229(3):949-952. doi:10.1016/j.psychres.2015.07.009
Kantak PA, Bobrow DN, Nyby JG. Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG). Behav Pharmacol. 2014;25(1):71-79. doi:10.1097/FBP.0000000000000013
Messaoudi M, Violle N, Bisson JF, Desor D, Javelot H, Rougeot C. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes. 2011;2(4):256-261. doi:10.4161/gmic.2.4.16108
Kodak T, Bergmann S. Autism Spectrum Disorder: Characteristics, Associated Behaviors, and Early Intervention. Pediatr Clin North Am. 2020;67(3):525-535. doi:10.1016/j.pcl.2020.02.007
Wan H, Zhang C, Li H, Luan S, Liu C. Association of maternal diabetes with autism spectrum disorders in offspring: A systemic review and meta-analysis. Medicine (Baltimore). 2018;97(2):e9438. doi:10.1097/MD.0000000000009438
Madra M, Ringel R, Margolis KG. Gastrointestinal Issues and Autism Spectrum Disorder. Child Adolesc Psychiatr Clin N Am. 2020;29(3):501-513. doi:10.1016/j.chc.2020.02.005
Li Q, Han Y, Dy A. The Gut Microbiota and Autism Spectrum Disorders. Front Cell Neurosci. 2017;11:120.
.Tomova A, Husarova V, Lakatosova S, Bakos J. Gastrointestinal microbiota in children with autism in Slovakia. Physiol Behav. 2015;138:179-187.
Gale SA, Acar D, Daffner KR. Dementia. Am J Med. 2018;131(10):1161-1169. doi:10.1016/j.amjmed.2018.01.022
Rogers J, Shen Y. A perspective on inflammation in Alzheimer’s disease. Ann N Y Acad Sci. 2000;924:132-135. doi:10.1111/j.1749-6632.2000.tb05571.x
Wu SC, Cao ZS, Chang KM, Juang JL. Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila. Nat Commun. 2017;8(1):24. doi:10.1038/s41467-017-00040-6
Vogt NM, Kerby RL, Dill-McFarland KA, et al. Gut microbiome alterations in Alzheimer’s disease. Sci Rep. 2017;7(1):13537. doi:10.1038/s41598-017-13601-y
Kazemi A, Noorbala AA, Azam K, et al. Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clin Nutr. 2019;38(2):522-528. doi: 10.1016/j.clnu.2018.04.010.
into-Sanchez MI, Hall GB, Ghajar K et al. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017;153(2):448-459.e8. doi: 10.1053/j.gastro.2017.05.003.
Derechos de autor 2024 Yaneth Citlalli Orbe Orihuela, José Ángel Hernández Mariano , Ana Cristina Castañeda Márquez , Alejandro Alvarado Delgado
Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-SinObrasDerivadas 4.0.
