Metronidazole induced encephalopathy
Abstract
Metronidazole, a commonly used antibiotic, is a drug of the family of 5-nitroimidazoles, which has antiparasitic and antibacterial properties in anaerobic organisms. A number of side effects to its use has been described, rare adverse effects also has been reported, included Metronidazole Induced Encephalopathy (MIE). MIE is potentially reversible neurological disorder. It is characterized by central and peripheral neurological disorders such as dysarthria, disturbances in consciousness, ataxic gait, paraesthesia, polyneuropathy, and less frequently seizures occur. The diagnosis is based on the clinic, identifying the history of consumption of Metronidazole and evidencing hyperdense images at the level of the dentate ganglia on a nuclear magnetic resonance imaging of the skull, with reversal of the picture after suspending the consumption of Metronidazole. It is important not only to identify the clinical picture to suspend the consumption of this drug, also, it is necessary inform to patients about the possible adverse effects of Metronidazole use, included MIE.
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References
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