Antinociceptive and anti-inflammatory activities of Curcumin

  • Marco Antonio de Paz Campos Universidad Autónoma del Estado de Hidalgo
Keywords: Curcumin, inflammation, pain, analgesia, anti-inflammatory effect.

Abstract

Curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric (Curcuma longa) used by men in the exage as medicinal remedy and spice. In the last decades the curcumin has been an object of multiple studies in vitro and in vivo that have established the scientific bases of their numerous therapeutic activities, emphasizing their powerful anti-inflammatory, anti-cancer and antioxidant properties. In the present work a revision of the anti-inflammatory mechanisms of action is made that include the inhibition of several cell signalling pathways at multiple levels and downregulates cellular enzyme like cyclooxygenase, lipoxygenase and nitric oxide synthase. Also the preclinical and clinical studies that have been carried out in this aspect are mentioned, the support, safety and efficiency of the curcumin used with analgesic and antiinflammatory purposes.

References

1 Ammon HP, Walh MA. Pharmacology of Curcuma longa. Planta Med. 1991; 57:1-7.

2 Srinivas L, Shalini VK, Shylaja M. Turmeric: a water soluble antioxidant peptide from turmeric (Curcuma longa). Arch. Biochem. Biophys. 1992;292: 617-623.

3 Pan MH, Huang TM, Lin JK. Biotransformation of curcumin through reduction and glucuronidation in mice Drug Metab. Dispos. 1999;27:486-494.

4 Nita Chainani-Wu. Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric (Curcuma longa). J. Altern. Complement Med. 2003; 1: 161–168.

5 Kohli K, Ali J, Ansari MJ, Raheman Z. Cucumin: A natural antiinflammatory agent. Indian J. Pharmacol. 2005; 37:141-147.

6 Mesa MD, Ramírez-Tortosa MC, Aguilera CM, Ramírez-Boscá A, Gil A. Efectos farmacológicos y nutricionales de los extractos de Curcuma longa y de los cucuminoides. Ars. Pharmaceutica, 2000; 41:3: 307-321.

7 Shishir Shishodia, Gautam Sethi and Bharat B. Aggarwal. Curcumin:Getting back to the roots. Ann. N.Y. Acad. Sci. 2005;1056:206-217.

8 Srimal RC, Dhawan BN. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J. Pharm. Pharmac. 1973; 25: 447-452.

9 Deodhar SD, Sethi R, Srimal RC. Preliminary study on antirheumatic activity of curcumin (Diferuloyl methane). Indian J. Med. Res. 1980; 71: 632-643.

10 Satoskar RR, Shah SJ, Shenoy SG. Evalaution of anti-inflammatory property of curcumin in patients with post operative inflammation. Int. J. Clin. Pharmacol. Ther. Toxicol. 1986; 24: 651-654.

11 Lal B, Kapoor AK, Asthana OP, Agrawal PK, Prasad R, Kumar P. Efficacy of curcumin in the management of chronic anterior uveitis. Phytother. Res. 1999; 13: 318-322.

12 Lal B, Kapoor AK, Agrawal PK, Asthana OP, Srimal RC. Role of curcumin in idiophatic inflammatory orbital pseudotumors.Phytother. Res. 2000;14: 443-447.

13 Sharma S, Kulkarni SK, Agrewala JN, Chopra K. Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur. J. Pharmacol. 2006; 536: 256-261.

14 Sirvastava KC, Bordia A, Verma SK. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation an alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot. Essent. Fatty Acids. 1995 ; 52: 223-227.

15 Conney AH, Lysz T, Ferraro T, Abidi TF, Manchand PS.Inhibitory effectof curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin. Adv. Enzyme Regul. 1991; 31: 385-396.

16 Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J. Immunol. 1999; 163:3474-3483.

17 Handler N, Jaeger W, Puschacher H, Leisser K, Erker T. Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors. Chem. Pharm. Bull. (Tokyo). 2007; 55: 64-71.

18 Sirvastava R, Srimal RC. Modification of certain inflammation-induced biochemical changes by crcumin. Indian J. Med. Res. 1985; 81: 215-223.

19 Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD. Inhibitory effects of curcumin on in vitro lipoxigenase and ciclooxigenase activities in mouse epidermis. Cancer Res. 1991; 51: 813-819.

20 Flynn DL, Rafferty MF, Boctor AM. Inhibition of 5-hydroxy-eicosatetraenoico acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: Inhibitory activities of curcuminoids and yakuchinones. Prostaglandins Leukot. Med. 1986; 22: 357-360.

21 Lukita-Atmadja W, Ito Y, Baker GL, McCuskey RS. Effects of curcuminoids as anti-inflammatory agents on the hepatic microvascular response to endotoxin. Shock 2002; 17; 399-403.

22 Elizabeth K, Rao MNA. Oxygen radical scavening activity of curcunin. Int. J. Pharm. 1990; 58: 237-240.

23 Joe B, Lokesh BR. Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages. Lipids 1997; 32:1173-1180.

24 Tajik H, Tamaddonfard E, Hamzech-Gooshchi. Interaction between curcumin and opioid system in nthe formalin test. Pak. J. Biol. Sci. 2007; 10: 2538-2586.

25 Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001; 21:2895–2900.

26 Jheng-Yu WU, Chin-Yi Lin,Tien-Wei Lin,Chuian-Fu Ken,And Yu-Der Wen.Curcumin Affects Development of Zebrafish Embryo Biol. Pharm. Bull. 2007;30 :1336-1339.

27 Foryst-Ludwig A, Neumann M, Schneider-Brachert W, Naumann M. Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochem. Biophys. Res. Commun. 2004; 316:1065-1072.

28 Rafatullah S, Tariq M, Al-Yahya MA, Mossa JS, Ageel AM. Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J. Ethnopharmacol. 1990; 29: 25-34.

29 Kim DC, Kim SH, Choi BH, Baek NI, Kim D, Kim MJ, Kim KT Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biol. Pharm. Bull. 2005; 28: 2220-2224.

30 Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P, Sharma AV. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J. Biol. Chem. 2005; 280: 9409-9415.

31 Gupta B, Kulsherestha VK, Srivastava RK, Prasad DN. Mechanism of curcumin induced gastric ulcer in rats. Indian J Med. Res. 1980; 71: 806-814.

32 Rasyid A, Lelo A. The effect of curcumin and placebo on human gall-bladder function: An ultrasound study. Aliment. Pharmacol. Ther. 1999; 13: 245–249.

33 De Paz Campos MA. Valoración preclínica de la eficacia antiinflamatoria, antinociceptiva y seguridad gástrica de la curcumina (Cúrcuma longa). México, D.F.: CINVESTAV. IPN. 2009. Tesis para obtener el grado de Maestro en Ciencias.
Published
2013-07-05