Bioactive Compounds and Antihypertensive Activity of Extracts of Hibiscus sabdariffa L
Keywords:
systemic arterial hypertension, extracts of Hibiscus sabdariffa, antihypertensive, treatment
Abstract
Introduction: systemic arterial hypertension (SAH) is the main risk factor for the developing of cardiovascular disease, which the leading cause of death worldwide. One of the best ways to control blood pressure (BP) levels is the combination of lifestyle changes and drug therapy. However, pharmacotherapy is expensive and produces adverse reactions. Thus, it is necessary to find cheap, safe and effective alternative treatments. Hibiscus sabdariffa L. (HS) is a plant that is traditionally used in some countries to treat SAH, which has given rise to various investigations to determine their compounds and their antihypertensive activity. Aim: the present article aims at reviewing the reports that support the antihypertensive activity of extracts from HS in animal and human models Conclusions: the information collected from scientific literature suggests that HS extracts have antihypertensive effects in animals and humans, especially in early stages; however, more studies in advanced stages of hypertension are needed.
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References
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Sesma-Vázquez S, Pérez-Rico R, Sosa-Manzano CL, Gómez-Dantés O. Gastos catastróficos por motivos de salud en México: magnitud, distribución y determinantes. Salud Públ. Méx. 2015;47(1):37-46.
Arévalo M, López M, López D, Martínez F. Adherencia a la terapéutica farmacológica en pacientes con hipertensión arterial. Rev. Méd. HJCA. 2016;8(1):8-13.
Veliz-Rojasa L, Mendoza-Parrab, Barrigac OA. Adherencia terapéutica y control de los factores de riesgo cardiovasculares en usuarios de atención primaria. Enfer. Univ. 2015;12(1):3-11.
Chaupis-Meza D, Rojas J, Gasco M, Gonzales GF. Efecto hipotensor del extracto de ajo (Allium sativum) macerado por 18 semanas en un modelo experimental in vivo. Rev. Peru. Med. Exp. Salud Publica. 2014;31(3):461-466.
Dalí E. Nuevas aportaciones obre efectos del espino blanco (Crataegus sp) en patología cardiovascular. Rev. Fitoter. 2009;9(S1):69-74.
Rojas J, Ronceros S, Palomino R, Salas M, Azañero R, Cruz H, et al. Efecto coadyuvante del extracto liofilizado de Passiflora edulis (maracuyá) en la reducción de la presión arterial en pacientes tratados con enalapril. An. Fac. med. 2009;70(2):103-108.
López M. Las plantas medicinales en el tratamiento de la HTA. Offarm. 2001; 20:112-117.
Cid-Ortega S, Guerrero-Beltrán JA. Propiedades funcionales de la Jamaica (Hibiscus sabdariffa L.). TSIA. 2012;6(2):47-63.
Salazar-González C, Vergara-Balderas FT, Ortega-Regules AE, Guerrero-Beltrán, JA. Antioxidant properties and color of Hibiscus sabdariffa extracts. Cien. Inv. Agr. 2012;39(1):79-90.
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Guardiola S, Mach N. Potencial terapéutico del Hibiscus sabdariffa: una revisión de las evidencias científicas. Rev. Endocrinol. Nutr. 2014;61(5):274-295.
Da-Costa-Rocha I, Bonnlaender B, Sievers H, Pischel I, Heinrich M. Hibiscus sabdariffa L. A phytochemical and pharmacological review. Food. Chem. 2014; 165:424-443.
Odigie IP, Ettarh RR, Adigun SA. Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. J. Ethnopharmacol. 2003; 86: 181–185.
Ramírez-Cortés B, Caro-Velarde F, Valdivia-Reynoso MG, Ramírez-Lozano MH, Machuca-Sánchez ML. Cambios en tamaño y características químicas de cálices de jamaica (Hibiscus sabdariffa L.) durante su maduración. Rev. Chapingo Ser. Hortic. 2011;8(2):19-31.
Padmaja H, Sruthi S, Vangalapati M. Review on Hibiscus sabdariffa a valuable herb. Int. J. Pharm. Life Sci. 2014;5(8):3747-3752.
McKay DL, Oliver Chen CY, Saltzman E, Blumberg JB. Hibiscus Sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J. Nutr. Desease. 2009; 140:298-303.
Chukwu ND, Ikemefuna AE, Fidelis OL, Zuada NN. Effects of aqueous extract of Hibiscus sabdariffa on the reninangiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril. Indian J. Pharmacol. 2015;47(5):540–545.
Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F, Noori-Shadkam M. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J. Hum. Hypertens. 2009; 23:48-54.
Sumaya-Martínez M, Medina-Carrillo RE, Machuca-Sánchez M, Jiménez-Ruiz E, Balois-Morales R, Sánchez-Herrera LM. Potencial de la jamaica (Hibiscus sabdariffa L.) en la elaboración de alimentos funcionales con actividad antioxidante. Rev. Mex. Agr. 2014;35(18):1082-1807.
Lin HH, Chen JH, Wang CJ. Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne. Curr. Med. Chem. 2011;18(8):1245-1254.
Carvajal-Zarrabal O, Barradas-Dermitz DM, Orta-Flores Z, Hayward-Jones PM, Nolasco-Hipólito C, Aguilar-Uscanga G, et al. Hibiscus sabdariffa L., roselle calyx, from ethnobotany to pharmacology. J. Pharmacol. Exp. 2012; 4:25–39.
Guzmán-Ortiz FA, Román-Gutiérrez AD, Castro-Rosas J, Gómez-Aldapa CA, Falfán-Cortés RN, Rodríguez-Marín ML. Compuestos bioactivos como una alternativa viable para disminuir la incidencia de enfermedades crónicas no transmisibles. In: Díaz Batalla L, Gómez-Aldapa CA, Castro-Rojas J, Téllez Jurado A, editors. Biotecnología y alimentos en Hidalgo: transitando a la bioeconomía. 1st ed. México: Amalgama Arte Editorial S.A. de C.V.; 2016:1-305.
Herranz-López M, Olivares-Vicente M, Encinar JA, Barrajón-Catalán E, Segura-Carretero A, Joven J, et al. Multi-targeted molecular effects of Hibiscus sabdariffa polyphenols: an opportunity for a global approach to obesity. Nutrients. 2017;9(907):1-26.
Hopkins AL, Lamm MG, Funk J, Ritenbaugh C. Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: a comprehensive review of animal and human studies. Fitoterapia. 2013; 85:84–94.
Ojedaa D, Jiménez-Ferrer, E, Zamilpa A, Herrera-Arellano A, Tortoriello J, Álvarez L. Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa. J. Ethnopharmacol. 2010; 127:7–10.
Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J. Hypertens. 2015;33(6):1119-1127.
Castañeda R, Cáceres A. Compuestos bioactivos y propiedades terapéuticas de los cálices de rosa de jamaica (Hibiscus sabdariffa Linn). Rev. Cien. 2014;24(1):7-24.
Alarcon-Aguilar FJ, Zamilpa A, Perez-Garcia MD, Almanza-Perez JC, Romero-Nunez E, Campos-Sepulveda EA, et al. Effectof Hibiscus sabdariffa on obesity in MSG mice. J. Ethnopharmacol. 2007; 114:66-71.
Frank T, Netzel G, Kammerer DR, Carle R, Kler A, Riesl E, et al. Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects. J. Sci. Food. Agric. 2012; 92:2207-2218.
Ali BH, Mousa HM, El-Mougy S. The effect of a water extract and anthocyanins of Hibiscus sabdariffa L on paracetamolinduced hepatoxicity in rats. Phytother. Res. 2003; 17:56-59.
Chen CC, Hsu JD, Wang SF, Chiang HC, Yang MY, Kao ES, et al. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem. 2003; 51:5472-5477.
Carvajal-Zarrabal O, Waliszewski SM, Barradas-Dermitz DMA, Orta-Flores Z, Hayward-Jones PM, Nolasco-Hipolito C, et al. The consumption of Hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats. Plant Food Hum. Nutr. 2005; 60:153-159.
Gurrola-Diaz CM, Garcia-Lopez PM, Sanchez-Enriquez S, Troyo-Sanroman R, Andrade-Gonzalez I, Gomez-Leyva JF. Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). Phytomed. 2010; 17:500-505.
Mohagheghi A, Maghsoud S, Khashayar P, Ghazi-Khansari. The effect of Hibiscus sabdariffa on lipid profile, creatinine, and serum electrolytes: a randomized clinical trial. ISRN Gastroenterol. 2011; 2011:976019.
Márquez VR, De La Rosa TC, Rivero CA, Medina MM. Actividad diurética del extracto total acuoso de los cálices de Hibiscus sabdariffa L. administrado en ratas albinas variedad Wistar. Sci. Tech. Año XIII. 2007; 33:377-381.
Joven J, March I, Espinel E, Fernández-Arroyo S, Rodríguez-Gallego E, Aragonés G, et. al. Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function. Mol. Nutr. Food Res. 2014;58:1374–1378.
Herrera-Arellano A, Flores-Romero S, Chávez-Soto MA, Tortoriello J. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine. 2004;11:375-382.
Herrera-Arellano A, Miranda-Sánchez J, Ávila-Castro P, Herrera-Álvarez S, Jiménez-Ferrer JE, Zamilpa A, et al. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, Lisinopril-Controlled clinical trial. Planta med. 2007;73:6-12.
Ndu OO, Nworu CS, Ehiemere CO, Ndukwe NC, Ochiogu IS. Herb-drug interaction between the extract of Hibiscus sabdariffa L. and hydrochlorothiazide in experimental animals. J. Med. Food. 2011; 14:640-644.
Akindahunsi AA, Olaleye, MT. Toxicological investigation of aqueous-methanolic extract of the calyces of Hibiscus sabdariffa L. J. Ethnopharmacol. 2003; 89:161-164.
Fakeye TO, Pal A, Bawankule DU, Yadav NP, Khanuja SP. Toxic effects of oral administration of extracts of dried calyx of Hibiscus sabdariffa Linn. (Malvaceae). Phytother. Res. 2009; 23:412-416.
Pan American Health Organization. Día Mundial de la Hipertensión. [internet] PAHO. 2016. [cited 2017 jul 10]. Available from: http://www.paho.org/hq/index.php?option=com_content&view=article&id=12023%3A1-may-2016-world-hypertensionday&catid=7261%3Aevents-1&Itemid=41080&lang=es.
Instituto Nacional de Salud Pública. Encuesta Nacional de Salud y Nutrición de Medio Camino 2016 (ENSANUT MC 2016) Informe final de resultados. [internet]. Cuernavaca, México: Instituto Nacional de Salud Pública. 2016. [cited 2017 jul 15]. Available from: http://www.epidemiologia.salud.gob.mx/doctos/encuestas/resultados/ENSANUT.pdf.
Sesma-Vázquez S, Pérez-Rico R, Sosa-Manzano CL, Gómez-Dantés O. Gastos catastróficos por motivos de salud en México: magnitud, distribución y determinantes. Salud Públ. Méx. 2015;47(1):37-46.
Arévalo M, López M, López D, Martínez F. Adherencia a la terapéutica farmacológica en pacientes con hipertensión arterial. Rev. Méd. HJCA. 2016;8(1):8-13.
Veliz-Rojasa L, Mendoza-Parrab, Barrigac OA. Adherencia terapéutica y control de los factores de riesgo cardiovasculares en usuarios de atención primaria. Enfer. Univ. 2015;12(1):3-11.
Chaupis-Meza D, Rojas J, Gasco M, Gonzales GF. Efecto hipotensor del extracto de ajo (Allium sativum) macerado por 18 semanas en un modelo experimental in vivo. Rev. Peru. Med. Exp. Salud Publica. 2014;31(3):461-466.
Dalí E. Nuevas aportaciones obre efectos del espino blanco (Crataegus sp) en patología cardiovascular. Rev. Fitoter. 2009;9(S1):69-74.
Rojas J, Ronceros S, Palomino R, Salas M, Azañero R, Cruz H, et al. Efecto coadyuvante del extracto liofilizado de Passiflora edulis (maracuyá) en la reducción de la presión arterial en pacientes tratados con enalapril. An. Fac. med. 2009;70(2):103-108.
López M. Las plantas medicinales en el tratamiento de la HTA. Offarm. 2001; 20:112-117.
Cid-Ortega S, Guerrero-Beltrán JA. Propiedades funcionales de la Jamaica (Hibiscus sabdariffa L.). TSIA. 2012;6(2):47-63.
Salazar-González C, Vergara-Balderas FT, Ortega-Regules AE, Guerrero-Beltrán, JA. Antioxidant properties and color of Hibiscus sabdariffa extracts. Cien. Inv. Agr. 2012;39(1):79-90.
SAGARPA-Tecnológico de Monterrey. Plan rector nacional sistema producto jamaica. Comité nacional sistema producto jamaica. [internet]. SAGARPA. 2012. [cited 2017 jul 20]. Available from: http://dev.pue.itesm.mx/sagarpa/nacionales/EXP_CNSP_JAMAICA/PLAN%20RECTOR%20QUE%20CONTIENE%20PROGRAMA%20DE%20TRABAJO%202012/PR_CNSP_JAMAICA_%202012.pdf.
Guardiola S, Mach N. Potencial terapéutico del Hibiscus sabdariffa: una revisión de las evidencias científicas. Rev. Endocrinol. Nutr. 2014;61(5):274-295.
Da-Costa-Rocha I, Bonnlaender B, Sievers H, Pischel I, Heinrich M. Hibiscus sabdariffa L. A phytochemical and pharmacological review. Food. Chem. 2014; 165:424-443.
Odigie IP, Ettarh RR, Adigun SA. Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. J. Ethnopharmacol. 2003; 86: 181–185.
Ramírez-Cortés B, Caro-Velarde F, Valdivia-Reynoso MG, Ramírez-Lozano MH, Machuca-Sánchez ML. Cambios en tamaño y características químicas de cálices de jamaica (Hibiscus sabdariffa L.) durante su maduración. Rev. Chapingo Ser. Hortic. 2011;8(2):19-31.
Padmaja H, Sruthi S, Vangalapati M. Review on Hibiscus sabdariffa a valuable herb. Int. J. Pharm. Life Sci. 2014;5(8):3747-3752.
McKay DL, Oliver Chen CY, Saltzman E, Blumberg JB. Hibiscus Sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J. Nutr. Desease. 2009; 140:298-303.
Chukwu ND, Ikemefuna AE, Fidelis OL, Zuada NN. Effects of aqueous extract of Hibiscus sabdariffa on the reninangiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril. Indian J. Pharmacol. 2015;47(5):540–545.
Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F, Noori-Shadkam M. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J. Hum. Hypertens. 2009; 23:48-54.
Sumaya-Martínez M, Medina-Carrillo RE, Machuca-Sánchez M, Jiménez-Ruiz E, Balois-Morales R, Sánchez-Herrera LM. Potencial de la jamaica (Hibiscus sabdariffa L.) en la elaboración de alimentos funcionales con actividad antioxidante. Rev. Mex. Agr. 2014;35(18):1082-1807.
Lin HH, Chen JH, Wang CJ. Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne. Curr. Med. Chem. 2011;18(8):1245-1254.
Carvajal-Zarrabal O, Barradas-Dermitz DM, Orta-Flores Z, Hayward-Jones PM, Nolasco-Hipólito C, Aguilar-Uscanga G, et al. Hibiscus sabdariffa L., roselle calyx, from ethnobotany to pharmacology. J. Pharmacol. Exp. 2012; 4:25–39.
Guzmán-Ortiz FA, Román-Gutiérrez AD, Castro-Rosas J, Gómez-Aldapa CA, Falfán-Cortés RN, Rodríguez-Marín ML. Compuestos bioactivos como una alternativa viable para disminuir la incidencia de enfermedades crónicas no transmisibles. In: Díaz Batalla L, Gómez-Aldapa CA, Castro-Rojas J, Téllez Jurado A, editors. Biotecnología y alimentos en Hidalgo: transitando a la bioeconomía. 1st ed. México: Amalgama Arte Editorial S.A. de C.V.; 2016:1-305.
Herranz-López M, Olivares-Vicente M, Encinar JA, Barrajón-Catalán E, Segura-Carretero A, Joven J, et al. Multi-targeted molecular effects of Hibiscus sabdariffa polyphenols: an opportunity for a global approach to obesity. Nutrients. 2017;9(907):1-26.
Hopkins AL, Lamm MG, Funk J, Ritenbaugh C. Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: a comprehensive review of animal and human studies. Fitoterapia. 2013; 85:84–94.
Ojedaa D, Jiménez-Ferrer, E, Zamilpa A, Herrera-Arellano A, Tortoriello J, Álvarez L. Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa. J. Ethnopharmacol. 2010; 127:7–10.
Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J. Hypertens. 2015;33(6):1119-1127.
Castañeda R, Cáceres A. Compuestos bioactivos y propiedades terapéuticas de los cálices de rosa de jamaica (Hibiscus sabdariffa Linn). Rev. Cien. 2014;24(1):7-24.
Alarcon-Aguilar FJ, Zamilpa A, Perez-Garcia MD, Almanza-Perez JC, Romero-Nunez E, Campos-Sepulveda EA, et al. Effectof Hibiscus sabdariffa on obesity in MSG mice. J. Ethnopharmacol. 2007; 114:66-71.
Frank T, Netzel G, Kammerer DR, Carle R, Kler A, Riesl E, et al. Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects. J. Sci. Food. Agric. 2012; 92:2207-2218.
Ali BH, Mousa HM, El-Mougy S. The effect of a water extract and anthocyanins of Hibiscus sabdariffa L on paracetamolinduced hepatoxicity in rats. Phytother. Res. 2003; 17:56-59.
Chen CC, Hsu JD, Wang SF, Chiang HC, Yang MY, Kao ES, et al. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem. 2003; 51:5472-5477.
Carvajal-Zarrabal O, Waliszewski SM, Barradas-Dermitz DMA, Orta-Flores Z, Hayward-Jones PM, Nolasco-Hipolito C, et al. The consumption of Hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats. Plant Food Hum. Nutr. 2005; 60:153-159.
Gurrola-Diaz CM, Garcia-Lopez PM, Sanchez-Enriquez S, Troyo-Sanroman R, Andrade-Gonzalez I, Gomez-Leyva JF. Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). Phytomed. 2010; 17:500-505.
Mohagheghi A, Maghsoud S, Khashayar P, Ghazi-Khansari. The effect of Hibiscus sabdariffa on lipid profile, creatinine, and serum electrolytes: a randomized clinical trial. ISRN Gastroenterol. 2011; 2011:976019.
Márquez VR, De La Rosa TC, Rivero CA, Medina MM. Actividad diurética del extracto total acuoso de los cálices de Hibiscus sabdariffa L. administrado en ratas albinas variedad Wistar. Sci. Tech. Año XIII. 2007; 33:377-381.
Joven J, March I, Espinel E, Fernández-Arroyo S, Rodríguez-Gallego E, Aragonés G, et. al. Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function. Mol. Nutr. Food Res. 2014;58:1374–1378.
Herrera-Arellano A, Flores-Romero S, Chávez-Soto MA, Tortoriello J. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine. 2004;11:375-382.
Herrera-Arellano A, Miranda-Sánchez J, Ávila-Castro P, Herrera-Álvarez S, Jiménez-Ferrer JE, Zamilpa A, et al. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, Lisinopril-Controlled clinical trial. Planta med. 2007;73:6-12.
Ndu OO, Nworu CS, Ehiemere CO, Ndukwe NC, Ochiogu IS. Herb-drug interaction between the extract of Hibiscus sabdariffa L. and hydrochlorothiazide in experimental animals. J. Med. Food. 2011; 14:640-644.
Akindahunsi AA, Olaleye, MT. Toxicological investigation of aqueous-methanolic extract of the calyces of Hibiscus sabdariffa L. J. Ethnopharmacol. 2003; 89:161-164.
Fakeye TO, Pal A, Bawankule DU, Yadav NP, Khanuja SP. Toxic effects of oral administration of extracts of dried calyx of Hibiscus sabdariffa Linn. (Malvaceae). Phytother. Res. 2009; 23:412-416.
Published
2019-01-05
How to Cite
Montes-Rubio, P. Y., & Fabela-Illescas, H. E. (2019). Bioactive Compounds and Antihypertensive Activity of Extracts of Hibiscus sabdariffa L. Mexican Journal of Medical Research ICSA, 7(13), 12-18. https://doi.org/10.29057/mjmr.v7i13.3796
Section
Articles
