Evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus type 2

Keywords: Hypoglycaemic capacity, Phytochemicals, Phytoteraphy, diabetes type 2


Diabetes mellitus is a disease that is characterized by the chronic presence of blood glucose levels caused by a defect in the secretion of insulin or in the action of this hormone in the body which must be treated integrally with a multidisciplinary approach. The natural treatment of this disease is a common practice around the world, especially in Latin America, there are several clinical studies, in vivo or in vitro assays that focus on assessing the hypoglycemic capacity of various natural products used empirically by the population for years for the phytotherapeutic treatment of the disease as well as the chemicals related to the mechanism of action that produces the hypoglycaemic effect. In the present article, a brief review of the evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus 2


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Rojas E, Molina R. Definition, classification and diagnosis of diabetes mellitus.Rev. Venez. Endocrinol. Metab. 2012; 10(1):7–12.

Urbán-Reyes BR, Coghlan-López JJ, Castañeda-Sánchez O. Lifestyle and glycemic control in patients with Diabetes Mellitus at the first level of attention. Aten. Fam. 2015; 22(3):68–71.

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2012 (Suppl 1); 34(1):3.

Sanzana G MG, Durruty AP. Other specific types of diabetes mellitus. Rev. Méd. Clín. CONDES. 2016; 27(2):160-70.

International Diabetes Federation. Diabetes Atlas of International Diabetes Federation. [Internet]. Bruselas, Belgica: Karakas Print. 2015 [Consulted February, 2019]. available in https://www.fundaciondiabetes.org/upload/publicaciones_ficheros/95/IDF_Atlas_2015_SP_WEB_oct2016.pdf

Encuesta Nacional de Salud y Nutrición (ENSANUT). Encuesta Nacional de Salud y Nutrición de Medio Camino 2016. Informe final de resultados. [Internet] Instituto Nacional de Salud Pública. 2017. Consulted February, 2019 available in https://www.gob.mx/cms/uploads/attachment/file/209093/ENSANUT.pdf

Observatorio Mexicano de Enfermedades No Transmisibles. Asumiendo el control de la diabetes. [Internet] México: Fundación Mídete. 2016. Consulted February, 2019, available in http://oment.uanl.mx/wp-content/uploads/2016/11/FMidete_Asumiendo-Control-Diabetes-2016.pdf

Gil-Velázquez LE, Sil-Acosta MJ, Dominguez-Sánchez ER, Torres-Arreola L del P, Medina-Chávez JH. Clinical practice guide, diagnosis and treatment of type two diabetes mellitus. Rev. Med. Inst. Mex. Seguro Soc. 2013; 51(1):104–19.

Secretaría de Salud. Norma Oficial Mexicana NOM-015-SSA2-2010, para la prevención, tratamiento y control de la diabetes. 2015. Consulted February 7, 2019. Available in http://www.dof.gob.mx/normasOficiales/4215/salud/salud.htm

Rodríguez-Rivera N, Cuautle-Rodríguez P, Molina-Guarneros JA. Oral hypoglycemic agents for the treatment of diabetes mellitus type 2: use and regulation in Mexico. Rev. Hosp. Juarez. 2017; 84(4):203–2011.

Rodríguez Lay G. Insulinoteraphy. Rev. Med. Hered. 2003; 14(3):140–4.

García-Muñoz A. Nutritional study of cactus (Opuntia ficus-indica L. Miller) in its different types of cooking. Rev. Med. Inst. Mex. Seguro Soc. 2017; 13:47-53.

Maki Diaz G, Peña-Valdivia CB, Garcia Nava R, Arevalo Garza ML, Calderon-Zavala G, Anaya Rosales S. Physical and chemical characteristics of nopal vegetable (Opuntia ficus-indica) for export and local consumption. Agrociencias. 2015; 43:31–51.

Santiago-Lorenzo MR, López-Jiménez A, Saucedo- C, Cortés-Flores JI, Suárez-Espinosa DJJ. Nutrimental composition of the nopal vegetable produced with mineral and organic fertilization. Rev. Fitote. 2016; 39(4):403–7.

Fabela-Illescas HE, Ávila-Domínguez R, Hernández-Pacheco A, Ortega Ariza JA, Betanzos-Cabrera G. Effect of a nopal-based drink (Nopalea cochenillifera) in patients from a rural population in Hidalgo, Mexico; pilot clinical trial. Nutr. Hosp. 2015; 32(6):2710–4.

Ramírez Ortíz ME, Rodriguez Carmona OY, Hernández Rodríguez OS, Chel Guerrero L, Aguilar Méndez MA. Study of the hypoglycemic and antioxidant activity of Tronadora, wereque root and cactus root. In: Ramírez Ortiz, editor. Alimentos funcionales de hoy. Barcelona, Spain: Omniasciencies books. 2016: 143-180.

Martínez-Cruz M. Stevia rebaudiana Bertoni, A review. Cultiv. Trop. 2015; 36:5–15.

Salvador-Reyes R, Sotelo-Herrera M, Paucar-Menacho L. Study of Stevia (Stevia rebaudiana Bertoni) as a natural sweetener and its use for the benefit of health. Sci. Agropecu. 2014; 5(3):157–63.

Jarma A, Rengifo T, Araméndiz-Tatis H. Physiology of stevia (Stevia rebaudiana) in terms of radiation in the Colombian Caribbean. II. Growth analysis. Agron. Colomb. 2006; 24(1):38–47.

Bazotte R, Botion LM, Bracht A. Effect of Stevia rebaudiana on glucose tolerance in normal adult man. Braz. J. Med. Biol. Res. 1986; 19(6):771-4.

Suanarunsawat T, Klongpanichapak S, Rungseesantivanon S, Chaiyabutr N. Glycemic effect of stevioside and Stevia rebaudiana in streptozotocin-induced diabetic rats. Eastern J. Med. 2004; 9:51–56.

Ferreira EB, de Assis Rocha Neves F, da Costa MA, do Prado WA, de AraújoFunari Ferri L, Bazzote RB. Comparative effects of Stevia rebaudiana leaves and stevioside on glycaemia and hepatic gluconeogenesis. Planta Med. 2006 Jun; 72(8):691–6.

Jeffrey C. A review of the Cucurbitaceae. Bot. J. Linn. Soc. 1980; 81:233–47.

Carnide V, Barroso M do R. Cucurbitaceae: bases for genetic improvement. Horticul. Internal. 2006; 53:16–21.

Delgado-Paredes GE, Rojas-Idrogo C, Sencie-Tarazona Á, Vásquez-Núñez L. Caracterization of fruits and seeds of some cucurbits in northern Perú. Rev. Fitotec. Mex. 2014; 37(1):7-20.

Frías-Tamayo JA, Ramírez-Peña G, de-la-Paz-Lorente C, Herrero-Pacheco C, Acosta-Campusano Y. Sechium edule (Jacq) sw: Phyoterapeutic as an antibacterial agent. Medisur. 2016; 14(6):664-70.

Sinagawa-García SR, Mora-Olivo A, Juárez-Aragón MC, Torres-Castillo JA. Wereke root (Ibervillea sonorae Greene) descriptive characteristics and biochemical generalities of its aqueous extract. Int. J. Exp Bot. 2015; 84:358-367.

Hernández Díaz AF, Ramirez-Sotelo G, Ortega Soto A. Producción de extractos de Ibervillea sonorae y su evaluación biológica in vitro e in vivo. Ciudad de México: Nacional Polythecnic Institute; 2011.

Hernández-Galicia E, Calzada F, Roman-Ramos R, Alarcón-Aguilar FJ. Monoglycerides and Fatty acids from Ibervillea sonorae Root: isolation and hypoglycemic activity. Planta Med. 2007; 73(3):236–40.

Alarcón-Aguilar FJ, Campos-Sepulveda AE, Xolalpa-Molina S, Hernández-Galicia E, Roman-Ramos R. Hypoglycaemic Activity of Ibervillea sonorae roots in healthy and diabetic mice and rats. 2008; 40(8):570-75.

Rivera-Ramírez F, Escalona-Cardoso GN, Garduño-Siliciano L, Galaviz-Hernández C, Paniagua-Castro N. Antiobesity and hypoglycaemic effects of aqueous extract of Ibervillea sonorae in mice Fed a high-fat diet with fructose. J. Biomed. Biotechnol. 2011; 11:1-6

Zapata-Bustos R, Alonso-Castro AJ, Gómez-Sánchez M, Salazar-Olivo LA. Ibervillea sonorae (Cucurbitaceae) induces the glucose uptake in human adipocytes by activating a PI3K-independent pathway. J. Ethnopharmacol. 2014; 152(3):546–52.

Antonio-Estrada C, Sánchez-Hernández MA, Alcántar-Vázquez J. Partial characterization of the chilacayote (Cucurbita ficifolia Bouché), as an alternative for industrial use for the region Cañada de Oaxaca. Temas Cienc. Tecnol. 2018; 22(66):3–12.

Saavedra JP, Xochicueponi J, Calderon M, Daniel D, Pérez C, Torres JB. Use of chilacayote (Cucurbita ficifolia) for the production of biotechnological products. Cent. Investig. óptica. 2015. Consulted Febraury 7, 2019. Available in https://www.researchgate.net/publication/328792634_Caracterizacion_parcial_del_chilacayote_Cucurbita_ficifolia_Bouche_como_alternativa_de_uso_industrial_para_la_region_Canada_de_Oaxaca

Basurto-Peña F, Castro-Lara D, Mera-Ovando LM, Juárez-Castro T. Ethnobotany of the cultivated pumpkins (Cucurbita spp.) In the Central Valleys of Oaxaca, Mexico.Agroproductividad. 2015; 8(1):47–53.

Curotto E, González G, O´Reilly S, Tapia G. Isolation and partial characterization of a protease from Cucurbita ficifolia. FEBS Lett. 1989; 243(2):363–365.

Acosta-Patiño JL, Jiménez-Balderas E, Juárez-Oropeza MA, Díaz- Zagoya JC. Hypoglycemic action of Cucurbita ficifolia on Type 2 diabetic patients with moderately high blood glucose levels. J. Ethnopharmacol. 2001; 77(1):99-101.

Alarcón-Aguilar FJ, Hernández-Galicia E, Campos-Sepulveda AE, Xolalpa-Molina S, Rivas.Vilchis JF, Vasquez Carrillo LI, Roman-Ramos R. Evaluation of the hypoglycemic effect of Cucurbita ficifolia Bouche (Cucurbitaceae) in different experimental models. J Ethnophar. 2002; 82(2-3):185–9.

Semeniuk LV, Bela AJ, Vonka CA, Romero MC, Nuñez MB. Phytochemical and nutritional composition of Momordica charantia and antioxidant activity. Dominguezia. 2018; 34(1):39–44.

Grover JK, Yadav SP. Pharmacological actions and potential uses of Momordica charantia: a review. J. Ethnoparmacol. 2004; 93(1):123–32.

Braca A, Siciliano T, D’Arrigo MD, Paola M. Chemical composition and antimicrobial activity of Momordica charantia seed essential oil. Fitoterapia. 2008; 79(2):123–5.

Raman A, Lau C. Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine. 1996; 2(4):349–62.

Muhammad Shoaib A. Trial of Linn (Karela) Powder in Patients with Maturity-Onset Diabetes. Universidad of Agriculture, Faisalabad. Consulted Febraury, 5 2019. Available in https://pdfs.semanticscholar.org/b2fc/9bbdf61725eeea769dc0eb9102e8f1c05cb1.pdf

Abas R, Othman F, Thent ZC. Protective Effect of Momordica charantia Fruit Extract on Hyperglycaemia-Induced Cardiac Fibrosis. Oxid. Med. Cell. Longev. 2014; 2014:429060.

Simpson R, Morris GA. The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review. Bioact. Carb. Diet Fibre. 2014; 3(2):106–14.

Morton, J.F. The chayote, a perennial, climbing, subtropical vegetable. Proceedings of the Florida State Horticultural Society, 1984; 94:240–245. Consulted Febraury 13, 2019. Available in http://agris.fao.org/agris-search/search.do?recordID=US8230331

Diré GF, Rodrigues JS, Oliveira JC, Vasconcelos SD, Siqueira PR, Duarte RM, Fernandes ML, Bernardo-Filho M. Biological effects of a chayote extract in Wistar rats with induced diabetes: a radiopharmaceutical analysis. Pak. J. Biol. Sci. 2007; 10(4):568–574.

Gajar A-M, Badrie N. Processing and Quality Evaluation of a Low-Calorie Christophene Jam (Sechium edule (Jacq.) Swartz. J. Food Sci. 2002; 67(1): 341–346.

Pérez-Avila KG. Hypoglycemic property of Sechium edule tested in an animal model. Michoacán: University of Morelia; (Pregrade thesis) 2013.

Siahaan JM. Effect of Antihipoglycemic Sechium edule Jacq. Swartz. Etanol Extract on Histopathologic Changes in Hyperglycemic Mus musculus L. J. Med. 2017; 2(2):86–93.

How to Cite
Perez-Avila, K. G., Vargas-De-León , C., Morales-González, J. A., & Madrigal-Santillán, E. (2020). Evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus type 2. Mexican Journal of Medical Research ICSA, 8(16), 56-64. https://doi.org/10.29057/mjmr.v8i16.3952