Inflammation in Cancer Development
Abstract
Inflammation plays an important role to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as inflammatory cells, carry out reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cancer cells within the TME are highly able to change their phenotypic and functional characteristics. Here, we review the relationship between inflammation and infection in cancer origins, and the mechanisms whereby inflammation and infection drive tumor formation. We discuss how infection promotes tumorigenesis related to inflammatory processes typically found in autoimmune diseases, release of inflammatory mediators induced by tumors, inflammation induced by therapy in cancer, and stimuli for induction of inflammation during tumorigenesis, including spatiotemporal considerations. A better understanding of the fundamental rules of engagement that govern the molecular and cellular mechanisms of tumor-promoting inflammation will be essential for further development of cancer therapies.
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References
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010; 140: 342–48.
Barber G. STING: infection, inflammation and cancer. Nat Rev Immunol. 2015; 15: 760–770.
Jacqueline C, Tasiemski A, Sorci G. Infections and cancer: the “fifty shades of immunity” hypothesis. BMC Cancer. 2017 17: 257.
Albrengues J, Shields MA, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V. Neutrophil extracelular traps produced during inflammation awaken dormant cancer cells in mice. Sience. 2018; 361: 4227.
Greten FR, Grivennikov SI. Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Immunity. 2019 Jul 16;51(1):27-41
Vyas D, Laput G, Vyas AK. Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis. Onco Targets Ther. 2014;7:1015-1023.
Di Maggio FM, Minafra L, Forte GI, Cammarata FP, Lio D, Messa C, Gilardi MC, Bravatà V. Portrait of inflammatory response to ionizing radiation treatment. J Inflamm (Lond). 2015; 18;12:14.
Barabutis N, Schally AV, Siejka A. P53, GHRH, inflammation and cancer. EBioMedicine. 2018;37:557-562.
LorNakayama M, Oshima M. Mutant p53 in colon cancer. J Mol Cell Biol. 2019;11(4):267-276.
Yoshiyama H, Ueda K, Komano J, Iizasa H. Infection-Associated Cancers. J Oncol. 2020;2020:4979131.
Yang YM, Kim SY, Seki E. Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets. Semin Liver Dis. 2019;39(1):26-42.
Nejsum, L. N., & Andersen, Å. B. (2020). Infection and the role in cancer development. APMIS: acta pathologica, microbiologica, et immunologica Scandinavica, 128(2), 71.
