Correlation between periodontal disease and complications due Covid-19

Keywords: Periodontal disease, periodontitis, complications, COVID-19, SARS-CoV-2


COVID-19 became a pandemic that affected all health sectors, both public and private. In the area of dentistry, the main concern is centred on the growing dangers of the production of aerosols by dental procedures in daily practice. In addition to this, the scientific community has recently analysed the direct potential risk of the presence of periodontal disease with the increase in the severity of COVID-19. The objective of this work is to talk about a new SARS-CoV-2 virus, delving into those risk indicators as main elements to understand the role of the virus in the pathogenesis of periodontitis, remembering that periodontitis is the second leading cause of tooth loss in adults. This work aims at updating health professionals, retaking the importance of prevention and control of oral health, as well as of COVID-19. There are few findings in the literature on the direct relationship between both diseases, taking into account the different strains of the virus discovered and its changing symptomatology, scientific and clinical research has had delays in accessing more extensive information regarding this subject; however, one of the main pieces of evidence lies in the role that the oral cavity plays in the periodontal health of the patient's tissues, since these could serve as entrances for the severe acute respiratory syndrome coronavirus SARS-CoV-2, in addition to the pro-inflammatory state subdued by cytokines within periodontal disease that could contribute to the development of severe forms of COVID-19.


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Helmi MF, Huang H, Goodson JM, Hasturk H, Tavares M, Natto ZS. Prevalence of periodontitis and alveolar bone loss in a patient population at Harvard School of Dental Medicine. B. M. C. Oral. Health. 2019;19(1):1-10.

Fouad H, Bayaty A. Impact of COVID-19 on periodontal therapy: An overview. J. Oral. Res. 2020; S2(1):10-13.

Silva A, Pereira L, Lemos F, Machado F, Figueiredo A. Would periodontitis be a facilitating factor for COVID‐19 progression? Oral. Dis. 2021;10:1111.

Ejaz H, Alsrhani A, Zafar A, Javed H, Junaid K, Abdalla A, et al. COVID-19 and comorbidities: Deleterious impact on infected patients. J. Infect. Public Health. 2020;13(12):1833–1839.

Das S, Birangal S, Nikam A, Pandey A, Mutalik S, et al. Role of comorbidities like diabetes on severe acute respiratory syndrome coronavirus-2: A review. Life Sci. 2020;258:118202.

Gasmi A, Peana M, Pivina L, Srinath S, et al. Interrelations between COVID-19 and other disorders. Clin. Immunol. 2021;224:108651.

Guan W-J, Liang W-H, Zhao Y, Liang H-R, Chen Z-S, Li Y-M, et al. Comorbidity and its impact on 1590 patients with Covid-19 in China: A Nationwide Analysis. Eur. Respir. J. 2020;55:2000547.

Dziedzic A, Wojtyczka R. The impact of coronavirus infectious disease 19 (COVID‐19) on oral health. Oral. Dis. 2021;27(3):703–706.

Cecoro G, Annunziata M, Iuorio MT, Nastri L, Guida L. Periodontitis, Low-Grade Inflammation and Systemic Health: A Scoping Review. Medicina. 2020;56(6):272.

Lu C, Liu X, Jia Z. 2019-nCoV transmission through the ocular surface must not be ignored. The Lancet. 2020;395(10224):e39.

Ciotti M, Ciccozzi M, Terrinoni A, Jiang W, Wang C, Bernardini S. The COVID-19 pandemic. Crit. Rev. Clin. Lab. Sci. 2020;57(6):365–88.

Calatroni MI. SARS: Severe Acute Respiratory Syndrome or Urbani's Disease. Rev. Fac. Med. 2003;26(2):89–93.

Queen J, Queen N. The coronavirus that causes Middle East respiratory syndrome. Rev. Med. Clin. 2015;145(12):529–31.

Martu M, Maftei G, Sufaru I, Jelihovschi I, Luchian I, Hurjui L, et al. Covid-19 and periodontal disease ethiopathogenic and clinical implications. Rom. J. Oral. Rehabil. 2021;12(4):116-124.

Marouf N, Cai W, Said K, Daas H, Diab H, Chinta V, et al. Association between periodontitis and severity of COVID-19 infection: A case–control study. J. Clin. Period. 2021;48(4):483–91.

Gofur N. Impact of SARS-CoV-2 on periodontal tissue manifestation. J. Int. Oral. Heal. 2020;12(8):90.

Conti P, Ronconi G, Caraffa A, Gallenga C, Ross R, Frydas I, et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVID-19 or SARS-CoV-2). J. Biol. Chem. 2020;34(2):327–31.

Santos López G, Cortés Hernández P, Vallejo Ruiz V, Reyes Leyva J. SARS-CoV-2: generalities, origin and advances in treatment. Gac. Mex. 2021;(1):157.

Umakanthan S, Sahu P, Ranade A, Bukelo M, Rao J, Abrahao L, et al. Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgrad. Med. J. 2020;96(1142):753–8.

Sharma A, Ahmad Farouk I, Lal SK. COVID-19: A Review on the Novel Coronavirus Disease Evolution, Transmission, Detection, Control and Prevention. Vir. 2021;13(2):202.

Yüce M, Filiztekin E, Özkaya KG. COVID-19 diagnosis -A review of current methods. Biosens. Bioelect. 2021;172:3-11.

Langa L, Sallent L, Díez S. Interpretation of COVID-19 diagnostic tests. Fmc. 2021;28(3):167–73.

Sreepadmanabh M, Sahu AK, Chande A. COVID-19: Advances in diagnostic tools, treatment strategies, and vaccine development. J. Biosci. 2020;45(1):8-23.

Vargas Lara A, Schreiber Vellnagel V, Ochoa Hein E, López Ávila A. SARS-CoV-2: a bibliographic review of the most relevant topics and evolution of medical knowledge about the disease. N.C. T. 2020;79(3):185–96.

Adhikari SP, Meng S, Wu YJ, Mao YP, Ye RX, Wang Q-Z, et al. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect. Dis Pover. 2020;9(1):29.

Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, et al. Hematological findings and complications of COVID-19. Am. J. Hematol. 2020;95(7):834–47.

Gil R, Bitar P, Deza C, Dreyse J, Florenzano M, Ibarra C. Clinical picture of COVID-19. Rev. Med. Chi. 2021;32(1):20-29.

Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 2020; 12 (1).

Ruiz A, Jiménez M. SARS-CoV-2 and acute respiratory syndrome (COVID-19) pandemic. Ars. Pharma. 2020;61(2):63–79.

Maguiña C, Gastelo R, Tequen A. The new Coronavirus and the Covid-19 pandemic. RMH. 2020;31(2):125–31.

Suárez V, Suárez M, Oros S, Ronquillo E. Epidemiology of COVID-19 in Mexico: from February 27 to April 30, 2020. Rev. Clin. Esp. 2020;220(8):463-471.

Van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N. Engl. J. Med. 2020; 382: 1564-7.

Pérez A, Valdés J, Ortiz L. Clinical characteristics and severity of COVID-19 in Mexican adults. Gac. Mex. 2020;(5):156-158.

Girano Castaños J, Robello Malatto J. Relationship between obesity and periodontal disease: literature review. Horiz. Med. 2020;20(3):e1081.

Solís D, Pérez I, García A. Inflammatory mechanisms in periodontal destruction. Rev. Odont. Mex. 2020;(3):23.

Hurtado A, Bojórquez Y, Montaño M, López J. Bacteria associated with periodontal diseases. Oral. 2016;17(54):1374–8.

Könönen E, Gursoy M, Gursoy UK. Periodontitis: A Multifaceted Disease of Tooth-Supporting Tiss. J. Clin. Med. 2019;8( 8):1135.

Lindhe J, Karring T, Araújo M. Anatomy of periodontal tissues. Clinical periodontology and dental implantology, 2009; 1:3-48.

Northridge M, Kumar A, Kaur R. Disparities in Access to Oral Health Care. Annu. Rev. Public. Heal. 2020;41:513–35.

Mur N, García C, Castellanos M, Sexto N, Méndez C, Gamio W. The influence of obesity and atherosclerosis on the etiology and pathogenesis of periodontal diseases. Med. South. 2017;15: 93-106.

Valdés G, Pimentel B, García C. Chronic inflammatory periodontal disease in obese adult patients. Med. Cent. 2017;21(4):335–8.

Cárdenas P, Abril D, Gastelum G, González V. et al. Main Diagnostic Criteria of the New Classification of Periodontal Diseases and Conditions. J. Odontost. 2021;15:1-4.

Zeron A. The new classification of periodontal diseases. Rev. Asoc. Dent. Mex. 2018;75(3):122–4.

Pardo L, Hernánde z F. Periodontal disease: Epidemiological approaches for analysis as a public health problem. Rev. Salt. Pub. 2018;20(2):258–64.

Secretary of Health. Results of the epidemiological surveillance system of oral pathologies. Sivepab. 2019;1:16-46.

Practical Guide to Reducing the Global Burden of Disease for Periodontal Disease Health and Periodontal Diseases. IDF. 2020;11:7-35.

Artigas R, Sánchez R, Romero C, Lara A. Risk factors for periodontal disease. CCM. 2021; 26:25.

Fabri G. Potential-link-between-covid19-and-periodontitis-cytokine-storm-immunosuppression-and-dysbiosis. B. M. C. Oral. Heal. 2020;20:5.

Anand P, Jadhav P, Kamath K, Revanth S, Vijayalaxmi S, Anil S. A case-control study on the association between periodontitis and coronavirus disease (COVID-19). J. Periodon. 2021;2:1–7.

Selvaraj S, Nyi N, Siddharthan S, Wan N, Zeng W. Periodontal disease and COVID-19. J. Pharm. Res. Int. 2020;32(32):88–91.

Badran Z, Gaudin A, Struillou X, Amador G, Soueidan A. Periodontal pockets: A potential reservoir for SARS-CoV-2? Med. Hypotheses. 2020;143:109907.

Bertolini M, Pita A, Koo S, Cardenas A, Meethil A. Periodontal Disease in the COVID-19 Era: Potential Reservoir and Increased Risk for SARS-CoV-2. Pesqui. Bras. Odonto. Clin. Integr. 2020;20:1–5.

Mancini L, Quinzi V, Mummolo S, Marzo G, Marchetti E. Angiotensin-Converting Enzyme 2 as a Possible Correlation between COVID-19 and Periodontal Disease. J. Appl. Polym. Sci. 2020;10(18):6224.

Sahni V, Gupta S. COVID-19 & Periodontitis: The cytokine connection. Med. Hypotheses. 2020;144:1-11.

Pitones V, Chávez E, Hurtado A, González A, Serafín N. Is periodontal disease a risk factor for severe COVID-19 illness? Med. Hypotheses. 2020;144:233-678.

Aquino R, Hernández S. Severe COVID-19 Lung Infection in Older People and Periodontitis. J. Clin. Med. 2021;10(2):1–17.

Botros N, Iyer P, Ojcius D. Is there an association between oral health and severity of COVID-19 complications? Biomed. J. 2020;43(4):325–7.

Sánchez M, Toledo B, Zaita Y, Fimia R. Sars-cov-2 virus and periodontitis. Paideia. XXI. 2021;11(1):247–54.

Sukumar K, Tadepalli A. Nexus between COVID-19 and periodontal disease. J. Int. Med. Res. 2021;(3):49.

Ayaz A, Arshad A, Malik H, Ali H, Hussain E, Jamil B. Risk factors for intensive care unit admission and mortality in hospitalized COVID-19 patients. Acut. Crit. Car. 2020;35(4):249–54.

Xie J, Tong Z, Guan X, Du B, Qiu H, Slutsky AS. Critical care crisis and some recommendations during the COVID- 19 epidemic in China. Inten. Care. Med. 2020;46(5):837–40.

How to Cite
Herrera-Cruz , C. J. (2022). Correlation between periodontal disease and complications due Covid-19. Mexican Journal of Medical Research ICSA, 10(20), 51-58.