Potencial terapéutico y aplicaciones biotecnológicas de los productos apícolas en medicina veterinaria

Jenny Alondra García-Hernández; Gabriela Medina Pérez; Cristian Uriel Guerrero-Sánchez; Diana Patricia Carreón Camacho; Armando Zepeda Bastida; Evelyn Pérez Hernández

doi:10.29057/icap.v12iEspecial.15435

Autores/as

Jenny Alondra García-Hernández Instituto de Ciencias Agropecuarias https://orcid.org/0009-0003-4085-3809
Gabriela Medina Pérez Instituto de Ciencias Agropecuarias https://orcid.org/0000-0001-8673-941X
Cristian Uriel Guerrero-Sánchez Instituto de Ciencias Agropecuarias https://orcid.org/0009-0001-7262-9305
Diana Patricia Carreón Camacho Instituto de Ciencias Agropecuarias https://orcid.org/0000-0001-9259-9943
Armando Zepeda Bastida Instituto de Ciencias Agropecuarias https://orcid.org/0000-0003-0572-5206
Evelyn Pérez Hernández Instituto de Ciencias Agropecuarias https://orcid.org/0009-0000-9670-6208

DOI:

https://doi.org/10.29057/icap.v12iEspecial.15435

Palabras clave:

Antioxidante, Apiterapia, Miel, Propóleo, Polén, Veneno de abeja, cicatrización de heridas, Antinflamatorio, Antimicrobiano

Resumen

Las propiedades fisicoquímicas y biológicas de la miel y otros productos de la colmena, resaltando sus significativas actividades antibacterianas, antifúngicas y antivirales, así como sus efectos antiinflamatorios y antioxidantes, han sido de gran relevancia en los ultimos días. Aquí, nosotros describimos las aplicaciones terapéuticas de la miel y diversos productos apícolas en la práctica veterinaria; se exploran los usos prácticos en el tratamiento de heridas y quemaduras, el manejo de enfermedades respiratorias y digestivas, así como sus aplicaciones en contextos dermatológicos y quirúrgicos. Resalta por suimportancia el propóleo, el polen y el veneno de abeja, describiendo sus propiedades únicas y sus posibles usos veterinarios. Finalmente, se aborda la seguridad y las precauciones asociadas con el uso de la miel y los productos apícolas, incluyendo los riesgos y efectos adversos potenciales, discutiendo posibles aplicaciones y desarrollos futuros en este campo dentro de la medicina veterinaria.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

[1] Olas B. Bee products as interesting natural agents for the prevention and treatment of common cardiovascular diseases. Nutrients 2022, 14(11):2267. https://doi.org/10.3390/nu14112267

[2] Svetikiene D, Zamokas G, Jokubaite M, Marksa M, Ivanauskas L, Babickaite L, Ramanauskiene K. The Comparative Study of the Antioxidant and Antibacterial Effects of Propolis Extracts in Veterinary Medicine. Veterinary Sciences 2024, 11(8):375. https://doi.org/10.3390/vetsci11080375

[3] Serrano J. Propóleo: aplicaciones terapéuticas. Natura Medicatrix Revista Medica Para El Estudio Y Difusion De Las Medicinas Alternativas. 2003

[4] Seeley TD. Honeybee ecology: A study of adaptation in Social Life. Princeton University Press. 1985. 212 pág. https://www.jstor.org/stable/j.ctt7zvpg1

[5] Salamanca-Grosso G. Origen, naturaleza, propiedades fisicoquímicas y valor terapéutico del propóleo. Ibagué: Sello Editorial Universidad del Tolima, 2017.

[6] Vargas-Sánchez RD, Torrescano-Urrutia GR, Sánchez-Escalante A. El propóleos: conservador potencial para la industria alimentaria. Interciencia 2013, 38(10):705-711.

[7] Zulhendri F, Chandrasekaran K, Kowacz M, Ravalia M, Kripal K, Fearnley J, Perera CO. Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review. Foods 2021, 10:1360. https://doi.org/10.3390/foods10061360

[8] Almuhayawi MS. Propolis as a novel antibacterial agent. Saudi Journal of Biological Sciences 2020, 27(11):3079-3086. https://doi.org/10.1016/j.sjbs.2020.09.016

[9] Balata GF, Shamardl HE, Abd Elmoneim HM, Hakami AA, Almodhwahi MA. Propolis emulgel: a natural remedy for burn and wound. Drug Dev Ind Pharm 2018, 44(11):1797-1808. doi: 10.1080/03639045.2018.1496449.

[10] Giral T, Hugues B, Soto CJ. Suspensión oftálmica de propóleos-R: Una alternativa en el tratamiento de las oftalmopatias en animales afectivos. REDVET. Revista Electrónica de Veterinaria 2007, 8(9):1-6.

[11] de Groot AC. Propolis: a review of properties, applications, chemical composition, contact allergy, and other adverse effects. Dermatitis 2013, 24(6):263-82. doi: 10.1097/DER.0000000000000011.

[12] Lukanc B, Erjavec V. Treating Burns in Cats and Dogs Using Medical Honey. Acta Veterinaria-Beograd 2022, 72(1):77-81.

[13] Przybyłek I, Karpiński TM. Antibacterial Properties of Propolis. Molecules 2019, 24(11):2047. doi: 10.3390/molecules24112047

[14] Nefzi N, Pagliari S, Campone L, Megdiche-Ksouri W, Giarratana F, Cicero N, Ziino G, Nalbone L. Chemical Composition and Comprehensive Antimicrobial Activity of an Ethanolic Extract of Propolis from Tunisia. Antibiotics 2023, 12(5):802. https://doi.org/10.3390/antibiotics12050802

[15] Collatupa JLC, Sánchez-Tito MA. Antibacterial activity of a Peruvian propolis ethanolic extract against Streptococcus mutans. Revista Cubana de Investigaciones Biomédicas. 2021, 40(3):e1121.

[16] Velasquez BD, Gomez SPM. Actividad antimicrobiana de extractos etanólicos de propóleos obtenidos de abejas Apis mellifera. RIAA 2017, 8(1):185-193.

[17] Schnitzler P, Neuner A, Nolkemper S, Zündel C, Nowack H, Sensch KH, Reichling J. Antiviral activity and mode of action of propolis extracts and selected constituents. Phytotherapy Research 2010, 24(Suppl. 1):S20–S28. https://doi.org/10.1002/ptr.2868

[18] Huleihel M, Isanu V. Anti-herpes simplex virus effect of an aqueous extract of propolis. Isr Med Assoc J 2002, 4(11 Suppl):923-7.

[19] Rivera-Yañez CR, Ruiz-Hurtado PA, Reyes-Reali J, Mendoza-Ramos MI, Vargas-Díaz ME, Hernández-Sánchez KM, Pozo-Molina G, Méndez-Catalá CF, García-Romo GS, Pedroza-González A, Méndez-Cruz AR, Nieto-Yañez O, Rivera-Yañez N. Antifungal Activity of Mexican Propolis on Clinical Isolates of Candida Species. Molecules 2022, 27(17):5651. doi: 10.3390/molecules27175651

[20] Ożarowski M, Karpiński TM, Alam R, Łochyńska M. Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions. Microorganisms, 2022, 10(2):364. doi: 10.3390/microorganisms10020364

[21] da Silva PM, Gauche C, Valdemiro LG, Oliveira ACC, Fett R. Honey: Chemical composition, stability and authenticity. Food Chemistry 2016, 196(1):309-323. https://doi.org/10.1016/j.foodchem.2015.09.051

[22] El Sohaimy SA, Masry SHD, Shehata MG. Physicochemical characteristics of honey from different origins. Annals of Agricultural Sciences 2015, 60(2):279-287. https://doi.org/10.1016/j.aoas.2015.10.015

[23] Gomes S, Dias LG, Moreira LL, Rodrigues P, Estevinho L. Physicochemical, microbiological and antimicrobial properties of commercial honeys from Portugal. Food and Chemical Toxicology 2010, 48(2):544-548. https://doi.org/10.1016/j.fct.2009.11.029

[24] Repellin RL, Pitt KA, Lu M, Welker J, Noland EL, Stanley BJ. The effects of a proprietary Manuka honey and essential oil hydrogel on the healing of acute full-thickness wounds in dogs. Vet Surg 2021, 50(8):1634-1643. doi: 10.1111/vsu.13711.

[25] Chatzimisios K, Tsioli V, Brellou GD, Apostolopoulou EP, Angelou V, Pratsinakis ED, Cremers NAJ, Papazoglou LG. Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats. Animals (Basel) 2023, 14(1):36. doi: 10.3390/ani14010036.

[26] Hananeh W, Ismail ZB, Alshehabat M, Ali J. Review of animal models used to study effects of bee products on wound healing: Findings and applications. Bulletin of the Veterinary Institute in Pulawy 2015, 59:425-431. DOI:10.1515/bvip-2015-0062.

[27] Xu X, Sun L, Dong J, Zhang H. Breaking the cells of rape bee pollen and consecutive extraction of functional oil with supercritical carbon dioxide. Innovative Food Science & Emerging Technologies 2009, 10:42–48. https://doi.org/10.1016/j.ifset.2008.08.004

[28] Rzepecka-Stojko A, Stojko J, Kurek-Górecka A, Górecki M, Kabała-Dzik A, Kubina R, Moździerz A, Buszman E. Polyphenols from Bee Pollen: Structure, Absorption, Metabolism and Biological Activity. Molecules. 2015; 20(12):21732-21749. https://doi.org/10.3390/molecules201219800

[29] Farag SA, El-Rayes TA. Effect of Bee-pollen Supplementation on Performance, Carcass Traits and Blood Parameters of Broiler Chickens. Asian Journal of Animal and Veterinary Advances 2016, 11:168-177. DOI: 10.3923/ajava.2016.168.177

[30] Sierra-Galicia MI, Rodríguez-de Lara R, Orzuna-Orzuna JF, Lara-Bueno A, Ramírez-Valverde R, Fallas-López M. Effects of Supplementation with Bee Pollen and Propolis on Growth Performance and Serum Metabolites of Rabbits: A Meta-Analysis. Animals 2023; 13(3):439. https://doi.org/10.3390/ani13030439

[31] Wehbe R, Frangieh J, Rima M, El Obeid D, Sabatier JM, Fajloun Z. Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests. Molecules 2019, 24(16):2997. doi: 10.3390/molecules24162997.

[32] Bava R, Castagna F, Musella V, Lupia C, Palma E, Britti D. Therapeutic Use of Bee Venom and Potential Applications in Veterinary Medicine. Vet Sci 2023, 10(2):119. doi: 10.3390/vetsci10020119

[33] Cui Z, Zhou Z, Sun Z, Duan J, Liu R, Qi C, Yan C. Melittin and phospholipase A2: Promising anti-cancer candidates from bee venom. Biomedicine & Pharmacotherapy 2024, 179:17385. https://doi.org/10.1016/j.biopha.2024.117385

[34] Choi GM, Lee B, Hong R, Park S, Cho DE, Yeom M, Hahm DH. Bee venom phospholipase A2 alleviates collagen‑induced polyarthritis by inducing Foxp3⁺ regulatory T cell polarization in mice. Scientific Reports 2021, 11:3511. https://doi.org/10.1038/s41598-021-82298-x

[35] Lee HS, Kim YS, Lee KS, Seo HS, Lee CY, Kim KK. Detoxification of Bee Venom Increases Its Anti-inflammatory Activity and Decreases Its Cytotoxicity and Allergenic Activity. Appl Biochem Biotechnol 2021, 193(12):4068-4082. doi: 10.1007/s12010-021-03653-2.

[36] Gu H, Han SM, Park K-K. Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease. Toxins 2020, 12(3):195. https://doi.org/10.3390/toxins12030195

[37] Noori Al‑Waili A, Salom K, Al‑Ghamdi A, Ansari M J. Antibiotic, pesticide, and microbial contaminants of honey: Human health hazards. The Scientific World Journal 2012, 930849. https://doi.org/10.1100/2012/930849

[38] Morariu ID, Avasilcai L, Vieriu M, Lupu VV, Ioniuc I, Morariu BA, Lupu A, Morariu PC, Pop OL, Burduloi VM, Starcea IM, Trandafr L. A Comprehensive Narrative Review on the Hazards of Bee Honey Adulteration and Contamination. Journal of Food Quality 2024, Article ID 3512676, 13 pag. https://doi.org/10.1155/2024/3512676

[39] Schocken-Iturrino RP, Carneiro MC, Kato E, Sorbara JOB, Rossi OD, Gerbasi LER. Study of the presence of the spores of Clostridium botulinum in honey in Brazil. FEMS Immunology and Medical Microbiology 1999, 24:379-382.

[40] Vogt NA, Vriezen E, Nwosu A, Sargeant JM. A Scoping Review of the Evidence for the Medicinal Use of Natural Honey in Animals. Front Vet Sci 2021, 7:618301. doi: 10.3389/fvets.2020.618301.

[41] Martinez‑Armenta C, Camacho‑Rea MC, Martínez‑Nava G A, Espinosa‑Velázquez R, Pineda C, Gomez‑Quiroz LE, López‑Reyes A. Therapeutic potential of bioactive compounds in honey for treating osteoarthritis. Frontiers in Pharmacology 2021, 12:642836. https://doi.org/10.3389/fphar.2021.642836

[42] Erejuwa OO, Sulaiman SA, Wahab MS. Honey--a novel antidiabetic agent. Int J Biol Sci 2012, 8(6):913-34. doi: 10.7150/ijbs.3697.