Autonomous function and resting state in mild cognitive impairment: a pilot study
Abstract
Mild cognitive impairment (MCI) is a pathological precursor of dementia. Cerebral and cardiovascular diseases favor the development of MCI. This is a pilot study about MCI and cardiovascular autonomic modulation and a methodology was proposed to assess older adults with MCI by analyzing heart rate variability (HRV). Four older adults (66.8 ± 3 years) with MCI and 4 older adults (70.5 ± 6 years) without MCI participated in the study. HRV was assessed during a 5-min eyes-closed resting condition. A significant negative correlation between age and the absolute power of the high frequency related to Respiratory Sinus Arrhythmia was found, but there was not a significant difference in HRV between the two groups. Resting HRV did not contribute in identifying the presence of MCI. During assessments of HRV, larger samples and high-demanding tasks are suggested.
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Allen, J. J. B., Chambers, A. S. & Towers, D. N. (2007), The many metrics of cardiac chronotropy: A pragmatic primer and a brief comparison of metrics. Biological Psychology, 74, 243-262.
Beauchaine, Theodore. & Crowell, Sheila. E. (2020). The Oxford handbook of emotion dysregulation. Oxford University Press.
Choi, Sabrina., Baudot, Matthias., Vivas, Oscar., & Moreno, Claudia. M. (2021). Slowing down as we age: aging of the cardiac pacemaker's neural control. GeroScience, 44(1), 1–17. https://doi.org/10.1007/s11357-021-00420-3
De Meersman, R. E. (1993). Aging as a modulator of respiratory sinus arrhythmia. Journal of Gerontology, 48(2):B74-B78. https://doi.org/10.1093/geronj/48.2.b74
Drummond, Peter. D. (1990). Parasympathetic cardiac control in mild hypertension. Journal of Hypertension, 8(4):383–387.
Dusi, V. & Ardell, J. L. (2020). Brain-heart afferent-efferent traffic. In S. Govoni, P. Politim & E. Vanoli (Eds). Brain and heart dynamics. Switzerland: Springer Nature Switzerland.3-24
Ehtewish, H., Arredouani, A., & El-Agnaf, O. (2022). Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline. International Journal of Molecular Sciences, 23(11), 6144. MDPI AG. Retrieved from https://doi.org/10.3390/ijms23116144
Forte, G., Favieri, F. & Casagrande, M. (2019). Heart rate variability and cognitive function: a systematic review. Frontiers in Neuroscience, 13, 710. https://doi.org/10.3389/fnins.2019.00710
Gutiérrez-Robledo, L. M. G., García-Peña, M. C., Roa-Rojas, P. A. y Martínez-Ruiz, A. (2017). La Enfermedad de Alzheimer y otras demencias como problema nacional de salud. Documento de pos-tura, en Consejo Nacional de Ciencia y Tecnología (CONACyT), Academia Nacional de Medicina de México, México. [En línea]. Disponible en: https://www.anmm.org.mx/publicaciones/ultimas_publicaciones/ANM-ALZHEIMER.pdf Fecha de consulta: 27 de agosto de 2023.
Gyurak, A. & Ayduk, O. (2008). Resting respiratory sinus arrhythmia buffers against rejection sensitivity via emotion control. Emotion, 8(4):458-467. https://doi.org/10.1037/1528-3542.8.4.458
Koo, B. B., Blackwell, T., Ancoli-Israel, S., Stone, K. L., Stefanick, M. L., Redline, S., and Osteoporotic Fractures in Men (MrOS) Study Group (2011). Association of incident cardiovascular disease with periodic limb movements during sleep in older men: outcomes of sleep disorders in older men (MrOS) study. Circulation. 124(11): 1223-1231.
Leng, Y., Blackwell, T., Stone, K. L., Hoang, T. D., Redline, S., and Yaffe, K. (2016). Periodic Limb Mo-vements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia. Sleep. 39(10): 1807-1810.
Malliani, A., Lombardi, F. & Pagani, M. (1994). Power spectrum analysis of heart rate variability: A tool to explore neural regulatory mechanisms. British Heart Journal, 71,1-2.
Masi, Christopher. M., Hawkley, Louise. C., Rickett, Edith. M., and Cacioppo, John. T. (2007). Respiratory sinus arrhythmia and diseases of aging: obesity, diabetes mellitus, and hypertension. Biological psychology, 74(2):212–223.
Ostrosky-Solís, F. Ardila, A. & Rosselli, M. (1999). Neuropsi: A brief neuropsychological test battery in Spanish with norms by age and educational level. Journal of the International Neuropsychological Society, 5, 413-433.
Pascale, A. & Govoni, S. (2020). Brain-heart communication. In S. Govoni, P. Politim & E. Vanoli (Eds). Brain and heart dynamics. Switzerland: Springer Nature Switzerland. 26-41
Petersen, R.C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183-194.
Quadt, L., Critchley, H. & Nagai, Y. (2022). Cognition, emotion, and the central autonomic network. Autonomic Neuroscience, 238, 102948.
Rahal. D., Bower, J. E., Irwin, M. R, Fuligni, A. J. & Chiang, J. J. (2023). Resting respiratory sinus arrhythmia is related to emotion reactivity to social-evaluative stress. Journal of Affective Disorders, 320:725-734. https://doi.org/10.1016/j.jad.2022.09.100.
Rosales-Lagarde, A., Martínez-Alcalá, C.I., Rodríguez-Torres, E., Cubero-Rego, L. (2023). Alertamientos y movimientos periódicos de las piernas durante las etapas de sueño y deterioro cognitivo leve en adultos mayores. Estudio preliminar. CienciaUAT, 18(1): 41-62 (Jul-Dic 2023). https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1749
Shaffer. F., & Ginsberg, J. P. (2017). An overview of heart rate variability metrics and norms. Frontiers in Public Health,5:258.
Shi Y, Lin F, Li Y, Wang Y, Chen X, Meng F, Ye Q, Cai G. (2023) Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants. BMC Med.21(1):266. doi: 10.1186/s12916-023-02940-5.
Tarvainen, M. P., Niskanen, J. P., Lipponen, J. A., Ranta-Aho, P. O., Karjalainen, P. A. (2014). Kubios HRV-heart rate variability analysis software. Computer Methods and Programs in Biomedicine, 113, 210-220.
Witt, L.S., Rotter, J., Stearns, S.C. et al. (2018). Heart Failure and Cognitive Impairment in the Atherosclerosis Risk in Communities (ARIC) Study. J GEN INTERN MED 33, 1721–1728 https://doi.org/10.1007/s11606-018-4556-x.
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