Multi-enzyme biosensors for multi-parameter analysis with a single device
Abstract
In this work, the simulation of the voltammetric and chronoamperometric response of a multi-enzyme biosensor for the simultaneous analysis of glucose, cholesterol and triglycerides with a single device is reported. The results were processed using MLR multiple linear regression, PCR principal components regression and PLS partial least squares regression, finding that the best results are obtained with MLR processing the voltammetric information, obtaining relative error percentages of less than 10% on average
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References
Instituto Nacional de Estadística y Geografía, Principales causa de mortalidad por residencia habitual, grupos de edad y sexo del fallecido; 2013; http://www.inegi. org.mx/est/contenidos/proyectos/registros/vitales/mortalidad/ tabulados/ConsultaMortalidad.asp (accesado marzo 1, 2016).
Wacher-Rodarte, N., Epidemiología del síndrome metabólico, Gac. Méd. Méx., 2009, 145, 384.
Eggins, B. R., Chemical Sensors and Biosensors, John Wiley & Sons, Gran Bretaña, 2002.
del Valle, M., Electronic Tongues Employing Electrochemical Sensors, Electroanalysis, 2010, 22, 1539.
Mabbott, G. A., An Introduction to Cyclic Voltammetry, J. Chem. Educ., 1983, 60, 697.
Oldham, K. B., Myland, J. C., Modelling cyclic voltammetry without digital simulation, Electrochim. Acta, 2011, 56, 10612.
Miller, J.N., Miller, J.C, Estadística y quimiometría para química analítica, 4ª edición, Pearson Educación, España, 2002.
A. Chaubey y B. D. Malhotra, «Review. Mediated biosensors,» Biosens. Bioelectron., vol. 17, nº 1, pp. 441-456, 2002.
W. J. Albery, P. N. Bartlett y D. H. Craston, «Amperometric Enzime Electrodes Part II. Conducting Salts as Electrode Materials for the Oxidation of Glucose Oxidase,» J. Electroanal. Chem., vol. 194, nº 1, pp. 223-235, 1985.
A. C. F. Ribeiro, O. Ortona, S. M. N. Simoes, C. I. A. Santos, P. M. R. A. Prazeres, A. J. M. Valente, V. M. M. Lobo y H. D. Burrows, «Binary Mutual Diffusion coefficients of Aqueous Solutions of Sucrose, Lactose, Glucose, and Fructose in the Temperatura Range from (298.15 to 328.15) K),» J. Chem. Eng. Data, vol. 51, nº 1, pp. 1836-1840, 2006.
E. L. Cussler, Diffusion; mass transfer in fluid systems, U.S.A. : Cambridge University Press, 2009.
Z. Q. Ababneh, C. B. Berde, A. M. Ababneh, S. E. Maier y R. V. Mulkern, «In vivo lipid difussion coefficient measurements in rat bone marrow,» J. Mang. Reson., vol. 27, nº 1, p. 859, 2009.
