Alginate-TiO2 Micro-spheres as curcumin dosing systems
Abstract
Controlled release systems are in increasing development, due to the need that exists to achieve an optimal dosage, in the right place and the control of this dosage for long periods. Curcumin has shown various biological actions, mainly as an antioxidant, anticancer and antibacterial. On the other hand, titanium oxide (TiO2) and alginate (Alg) are widely used in biomedicine as carriers of active substances. In this work, alginate microspheres containing titanium oxide loaded with curcumin were synthesized. The resulting biomaterial showed a spherical morphology. The FTIR-ATR technique demonstrated the formation of the biomaterial, TGA was used to determine the thermal stability of the spheres. Also, the in vitro biocompatibility was evaluated, resulting in that the Alg/TiO2-Cur spheres did not present toxicity in human erythrocytes. Finally, curcumin release was evaluated. Therefore, the Alg/ TiO2-Cur spheres were found to be biocompatible and can be used as efficient vehicles for curcumin release.
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