Precision Nutrition for Dyslipidemias in HIV/AIDS
Abstract
The dyslipidemia associated with HIV/AIDS is multifactorial and constitutes a risk factor for the development of macrovascular complications: myocardial infarction and cerebrovascular disease, which affect the quality of life. At the beginning of the pharmacological treatments of patients with HIV/AIDS, dyslipidemias were associated with protease inhibitors (PI) and, later, with nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). Evidence indicates that the use of these antiretroviral drugs increases the expression of the sterile regulatory element binding protein (SREBP) gene, which is regulated by the SREBP1 gene; thus, increasing the expression of lipogenic genes.
Precision nutrition is an approach that aims at the individualized nutrition of the patient where the phenotype, genotype and physical activity practices of the subject under evaluation are considered; the objective of this clinical case report is to characterize and describe a patient's dyslipidemia with HIV a precision nutrition approach based on the patient's particular conditions and the functioning of the SRBEP1 protein, which regulates the expression of genes involved in lipogenesis.
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References
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