Efficacy of spironolactone in treatment of acne vulgaris. A systematic review
Abstract
Objective: To analyze the efficacy of spironolactone therapy in the treatment of acne vulgaris reported from 1980 to March 2021. Methods: A search was carried out in the following databases: Scopus, PubMed, Embase, Science direct, Cochrane Library and Google Scholar, those articles that reported the follow-up of patients with Acne Vulgaris treated with spironolactone were selected. Methodological quality was assessed by three reviewers using the Mixed Methods Appraisal Tool (MMAT), version 2018. Results: Fifteen articles with accompanying or comparative treatments or both and five articles with spironolactone monotherapy that were not complemented or compared were selected. Variable efficacy was reported in the 20 articles that were selected. The five adverse reactions most common in the studies analyzed were: menstrual disturbances, hyperkalemia, localized pigmentation at the treatment site, dizziness and fatigue. Conclusions: Consider that even with the diversity of types of studies, a large percentage of acne reduction is reported, therefore, the evidence indicates that the treatment could be effective under controlled conditions.
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References
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