Grignard reactions: over a hundred years of relevance
Abstract
Grignard reagents have been the most used organometallic compounds in the last hundred years. At the end of the 19th century, at the University of Lyon, Antoine Barbier decided to modify the Wagner-Saytzeff reaction and replaced Zn by Mg in the one-step method for alcohol synthesis, starting from organic halides and carbonyl compounds. Then, Victor Grignard, his PhD student, studied his professor’s reaction more profoundly. He identified the reactive species as RMgX and concluded that his yields could be improved by preparing these ones first, and then adding them to the carbonylic compound. The synthesis of Grignard reagents is strongly influenced by several factors such as solvents, magnesium activation modes, or the nature of the organic halide. These organomagnesium compounds are essential in synthetic chemistry because they behave as nucleophiles that can form carbon-carbon or carbon-heteroatom bonds.Downloads
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